ISSN 2398-2985      

Doxycycline

4ferrets

Introduction

Name

  • Doxycycline.

Class of drug

  • Lipid-soluble tetracycline antibiotic.

Description

Chemical name

  • (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide.

Molecular formula

  • C22H24N2O8.

Molecular weight

  • 444.44.

Physical properties

  • Available in hyclate, calcium and monohydrate salts.
  • Hyclate: used in the injectable dosage form and in oral tablets and capsules.
    • Also known as doxycycline HCl.
    • Yellow, crystalline powder.
    • Soluble in water and slightly soluble in alcohol.
  • Monohydrate: used in the oral powder for reconstitution.
    • Yellow, crystalline powder.
    • Very slightly soluble in water and sparingly soluble in alcohol.
  • Calcium salt: found in the oral syrup

Storage requirements

  • Tablets and capsules should be stored in tight, light resistant containers, at room temperature.
  • The hyclate injection, when reconstituted to up to 1 mg/mL may be stored refrigerated for 72 h.
  • Frozen reconstituted solutions (10 mg/mL) are stable for at least 2 months if kept at -20°C/-4°F.
  • If stored at room temperature, they are stable for 12-48 h.

Uses

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Indications

  • It is the tetracycline of choice when tetracyclines are indicated.
  • Appropriate for ferrets with renal impairment.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Antacids, calcium, magnesium and iron salts
  • Absorption of doxycycline reduced.
Phenobarbitone, phenytoin and primidone
  • Increase the metabolism of doxycycline thus decreasing the plasma levels.

with diagnostic tests

  • It may alter urine glucose determination.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Johnson-Delaney C A (2017) Ferret Medicine and Surgery. CRC Press, USA. pp 514.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.
  • Bishop Y (1998) Ed The Veterinary Formulary. British Veterinary Association and Royal Pharmaceutical Society.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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