Exotis ISSN 2398-2985

Ferrets

Diphenhydramine

Synonym(s): Diphenydramine HCl, Benadryl, Nytol, Dreemon

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Diphenhydramine.

Class of drug

  • Ethanolamine antihistamine.

Description

Chemical name

  • 2-diphenylmethoxy-N,N-dimethylethylethanamine.

Molecular formula

  • C17H21NO.

Molecular weight

  • 291.82.

Physical properties

  • Odorless, white crystalline powder.
  • Slowly darkens with light exposure.
  • Bitter tasting.
  • 1 g is soluble in 1 mL of water and 2 mL of alcohol.

Storage requirements

  • Room temperature.
  • Injectable solution should not be frozen.
  • Oral formulations should be kept in well-closed, tight containers.

Uses

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Indications

  • Used primarily for its antihistamine effects (prevention of motion sickness, cough suppressant, sedative, antiemetic, reduction of pruritus).
  • Used to treat adverse reactions to vaccines.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • CNS depressant drugs.
  • Antihistamines may partially counteract the effects of heparin or warfarin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, Gloucester, UK. pp 338.
  • Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell. pp 1296.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, Iowa, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

ADDED