ISSN 2398-2985      

Diltiazem

4ferrets

Introduction

Name

  • Diltiazem.

Class of drug

  • Class IV antidysrhythmic agent.
  • Calcium channel blocker.

Description

Chemical name

  • 1,5-benzothiazepim-4(5H)one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-monohydrochloride,(+)-cis-.

Molecular formula

  • C22H26N2O4S.

Molecular weight

  • 414.52.

Physical properties

  • White to off-white crystalline powder with bitter taste.
  • Soluble in water and alcohol. ​

Storage requirements

  • Store at room temperature in tight and light resistant containers.
  • The powder for injection should be stored at 15-30°C/59-86°F and discarded after 24 h of reconstitution.​

Uses

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Indications

  • Management of hypertrophic cardiomyopathy.
  • It may also be used for tachyarrhythmias.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Beta-adrenergic blockers, eg propranolol
  • If administered concurrently with propranolol there may be additive negative inotropic and chronotropic effects.
Calcium salts, Vitamin D
  • Diltiazem's activity may be adversely affected.
Cimetidine
  • Cimetidine inhibits the metabolism of diltiazem thereby increasing plasma concentrations.
Theophylline
  • Theophylline diltiazem enhances the effect, which may lead to toxicity.
Protein bound agents, eg warfarin
  • Diltiazem may displace warfarin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, UK. pp 338.
  • Fox J G & Marini R P (2014) Eds Biology and Diseases of the Ferret. 3rd ed. Wiley Blackwell, USA. pp 835.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, USA. pp 1120.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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