Exotis ISSN 2398-2985

Ferrets

Deslorelin

Synonym(s): Suprelorin

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Deslorelin.
  • Available veterinary formulation contains deslorelin as deslorelin acetate.

Class of drug

  • Gonadotrophin-releasing hormone (GnRH) agonist.

Description

Chemical name

  • (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide.

Molecular formula

  • C64H83N17O12.

Molecular weight

  • 1282.45.

Physical properties

  • White to pale yellow cylindrical implant (size of a microchip).
  • Implant is supplied in a pre-loaded implanter.

Storage requirements

  • Store in refrigerator (2-8°C/35.6-46.4°F).
  • Do not freeze.
  • Shelf-life of product packaged for sale: 2 years.

Uses

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Indications

  • Deslorelin implants have been researched with great extent in ferrets and their used is common for the prevention and treatment of a number of conditions.
  • As a general rule, it is used to prevent breeding, reduce aggression and reduce smell in males and to prevent breeding and prevent reproductive problems, eg hyperestrogenism, in females.
  • Also used for the treatment and prevention of adrenal disease.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • None known.
Warnings for personnel handling the product
  • Women in childbearing age should avoid contact with the product or wear disposable plastic gloves when handling the product.
  • ​Pregnant women should handle the product with extreme care.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • van Zeeland Y R A, Pabon M, Roest J et al (2014) Use of a GnRH agonist implant as alternative for surgical neutering in pet ferrets. Vet Rec 175 (3), 66 PubMed.
  • Bulliot C, Mentre V, Berthelet A et al (2014) Use of a Gonadotropin Releasing Hormone Agonist Implant Containing 4.7 mg Deslorelin for Medical Castration in Male Ferrets (Mustela putorius furo). Int J Appl Res Vet Med 12 (1), 67-75 VetMedResource.

Other sources of information

  • Meredith A (2015) Ed Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, Quedgeley, Gloucester, UK. pp 338.
  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, Iowa, USA. pp 1120.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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