Exotis ISSN 2398-2985

Ferrets

Amoxicillin/clavulanate

Synonym(s): Co-amoxiclav

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Amoxicillin/clavulanate.

Class of drug

  • Combination of amoxicillin and beta-lactamase resistant penicillin antibiotic.

Description

Chemical name

  • potassium;(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate.

Molecular formula

  • C24H27KN4O10S.

Molecular weight

  • 602.65.

Physical properties

  • Powder.
  • Tablets.
  • Suspension.

Storage requirements

  • In a cool and dry environment <25°C/77°F.
  • All tablets are individually wrapped in foil, moisture-resistant packaging; do not remove until administration.
  • Refrigerate oral suspension after reconstitution - discard if solution becomes dark or after 10 days.

Uses

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Indications

  • This combination is active against gram-positive and gram-negative organisms, including penicillinase producing E. coli and S. aureus.
  • Pseudomonas and Klebsiella are resistant.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Probenecid
  • Decreases the renal tubular secretion of penicillin antibiotics and thus prolongs their blood levels.
Aminoglycosides
  • Do not mix in the same syringe as aminoglycosides.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, Iowa, USA. pp 1120.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, Cheltenham, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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