ISSN 2398-2985      

Cimetidine

4ferrets

Introduction

Name

  • Cimetidine.

Class of drug

  • H2-antihistamine.

Description

Chemical name

  • N-cyano-N'-methyl-N"-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine.

Molecular formula

  • C10H16N6S.

Molecular weight

  • 252.34.

Physical properties

  • Tablets.

Storage requirements

  • In a dry environment.

Uses

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Indications

  • Gastric and duodenal ulcers.
  • Uremic gastritis.
  • Stress or drug-related erosive gastritis.
  • Esophagitis.
  • Hypersecretory conditions secondary to gastrinoma or mastocytosis.
  • Adjunctively to reverse metabolic alkalosis.
  • May be useful as an immunomodulating agent by preventing activation of suppressor T-cells by histamine, although evidence is lacking.

Administration

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Precautions

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Interactions

with other drugs

Drugs affected by cimetidine (increased plasma levels)
  • Beta-blockers, eg propranolol.
  • Calcium channel blockers, eg verapamil.
  • Diazepam.
  • Lidocaine.
  • Metronidazole.
  • Pethidine.
  • Phenytoin.
  • Quinidine.
  • Theophylline.
  • Warfarin.
  • Phenobarbital.
Sucralfate
  • Sucralfate may reduce bioavailability of H2 antagonists.
  • While there is little evidence to suggest that this is clinically significant it may be wise to administer sucralfate at least 30 min before cimetidine.
Antacids, digoxin, ketoconazole, metoclopropamide
  • Stagger oral doses of cimetidine when used with these drugs by 2 h.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
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