Exotis ISSN 2398-2985

Ferrets

Amoxicillin

Synonym(s): Amoxycillin

Contributor(s): Vetstream Ltd, David Perpinan

Introduction

Name

  • Amoxicillin.

Class of drug

  • Penicillin antibiotic.

Description

Chemical name

  • 6[D](-)-a-amino-p-hydroxyphenylacetamido] penicillanic acid.

Molecular formula

  • C16H19N3O5S.

Molecular weight

  • 365.40.

Physical properties

  • Acid-stable, beta-lactamase-susceptible.

Uses

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Indications

  • Active against certain gram-positive and gram-negative organisms.
  • Not active against those that produce penicillinases, eg some E. coli  and Staphylococcus aureus.
  • The more difficult gram-negative organisms (Pseudomonas spp and Klebsiella spp) are usually resistant.
  • Commonly used in combination with clavulanic acid to increase potency.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Bacteriostatic antimicrobials (chloramphenicol, erythromycin, tetracyclines, sulphonamides)
  • There is in vitro antagonism, but actual clinical significance is not clear.
Probenecid
  • Will decrease the renal tubular secretion of penicillin antibiotics and thus prolong their blood levels.

with diagnostic tests

  • Amoxicillin may cause false-positive urine glucose determinations when using cupric sulfate solution

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Plumb D C (2008) Plumb's Veterinary Drug Handbook. 6th edn. Blackwell Publishing, Iowa, USA. pp 1120.
  • Tennant B (1999) Small Animal Formulary. 3rd edn. BSAVA, Cheltenham, UK.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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