ISSN 2398-2985      

Musculoskeletal lymphoma

4ferrets

Synonym(s): Lymphoma, myeloma and leukemia of the bone


Introduction

  • Cause: unknown.
  • Signs: weaknes, lethargy, posterior ataxia and paresis, anorexia, loss of weight/condition.
  • Diagnosis: hematology, serum chemistry, radiography, spleen biopsy.
  • Treatment: surgical removal.
  • Prognosis: poor for skeletal lesions.

Pathogenesis

Etiology

  • Unknown.

Pathophysiology

  • Lymphosarcoma as a generalized disease and may invade the skeleton.
  • Lymphoma may metastasize particularly to the vertebra.
  • The invading tumor causes osteolytic lesions.
  • One report found a lobulated firm, light tan mass occupying the body of the lumbar vertebra:
    • The mass had invaded the bone marrow, adjacent bone, muscles and vertebral canal.
    • The bone was fractured Fractures.
    • The mass was a poorly demarcated and unencapsulated mass of neoplastic plasma cells.
    • The adjacent bone was necrotic and in some areas replaced by fibrous connective tissue.
    • A cystic bone lesion in the proximal humerus with a non-supporting lameness of the foreleg was also reported.
    • Lytic masses have been noted in various bones.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Suran J N & Wyre N R (2013) Imaging findings in 14 domestic ferrets (Mustela putorius furo) with lymphoma. Vet Radiol Ultrasound 54 (5), 522-531 PubMed.
  • Eshar D, Wyre N R, Griessmyr P, Durham A & Hoots E (2010) Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret. JAVMA 237 (4), 407-414 PubMed.
  • Marks A L, Gaschen L, Tully Jr T N, Grasperge B J, Rich G  A (2010) What is your diagnosis? Plasma Cell Neoplasia. JAVMA 237 (9), 1033-1034 PubMed.

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