Equis ISSN 2398-2977

Cardiovascular: first pass radionuclide angiocardiography

Synonym(s): Nuclear cardiac imaging

Contributor(s): Russel Malton, Rachel Murray


  • A method to perform first-pass radionuclide angiocardiography to measure left ventricular ejection fraction, as an index of cardiac performance.
  • Although the procedure has also been used to detect left-to-right cardiac shunts in horses, there are no recognized advantages over standard echocardiography   Heart: echocardiography  therefore it has not become a routine diagnostic procedure. 
  • Both first-pass radionuclide angiocardiography and gated radionuclide ventriculography  have been used in humans to evaluate valvular incompetence and studies in dogs have suggested potential clinical value in assessing the severity of mitral regurgitation   Heart: mitral regurgitation   and congestive heart failure   Heart: failure - overview  .
  • With the development of simpler, more user-friendly software programs, these techniques may ultimately have a proven clinical role in the clinical assessment of horses with suspected congestive heart failure. 
  • 99mTc-MDP has been used as the radiopharmaceutical for first-pass radionuclide angiocardiography in horses and 99mTc-labeled red blood cells have been used for radionuclide ventriculography.
  • See relevant references for details regarding techniques for first-pass radionuclide angiocardiography and radionuclide ventriculography.

Further Reading


Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Koblik P D, Hornof W J (1987) Use of first-pass nuclear angiocardiography to detect left-to-right cardiac shunts in the horse. Vet Radiol 28 (5), 177-180 VetMedResource.
  • Koblik P D, Hornof W J, Rhode E A et al (1985) Left ventricular ejection fraction in the normal horse determined by first-pass nuclear angiocardiography. Vet Radiol 26 (2), 53-62 VetMedResource.
  • Koblik P D, Hornof W J (1985) Diagnostic Radiology and Nuclear Cardiography. Vet Clin North Am Equine Pract (2), 289-309 PubMed.

Other sources of information

  • Daniel G B (1996) Myocardial Imaging II: Functional Scintigraphy. In: Handbook of Veterinary Nuclear Medicine.Eds: Berry C B & Daniel G B. Carolina State University, Raleigh, NC, USA. pp 115-121.