ISSN 2398-2977      

Blood: biochemistry - total bilirubin

pequis

Synonym(s): Direct and indirect bilirubin, conjugated and unconjugated bilirubin


Overview

  • Peripheral breakdown of red blood cells and myoglobin   →   unconjugated (indirect) bilirubin   →   bound to albumin   →   transported to liver   →   conjugated with glucuronic acid   →   excreted in bile.
  • Jaundice, with an increase in total bilirubin, may be primarily due to an increase in direct, or indirect bilirubin or both.

Sampling

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Tests

Methodologies

  • Van den Bergh method.
  • Colorimetric.
  • Measure [total bilirubin] and [direct bilirubin]   →   [indirect bilirubin] = difference (total bilrubin - direct bilirubin = indirect bilirubin). Indirect bilirubin liberated by a detergent.

Availability

  • Routine test, widely available.

Technique (intrinsic) limitations

  • Interpret results in conjunction with other laboratory results and clinical signs.

Technician (extrinsic) limitations

  • Routine test.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Engleking L R & Paradis M R (1987) Evaluation of hepatobiliary disorders in the horse. Vet Clin North Am Equine Pract (3), 563-583.
  • Ogilvie G K, Engleking L R & Anwe M S (1985) Effects of plamsa sample storage of on blood ammonia, bilirubin and urea nitrogen concentrations - cats and horses. Am J Vet Res 46 (12), 2619-2622.

Other sources of information

  • Barton M H & Morris D D (1998) Diseases of the Liver. In: Equine Internal Medicine. Eds: S M Reed & W M Bayly. W B Saunders Co, USA
  • Kaneko J J, Harvey J W & Bruss M L(1997) Eds. Clinical Biochemistry of Domestic Animals. 5th edn. Academic Press, USA.

Organisation(s)

  • Veterinary commercial laboratories, State diagnostic laboratories or Veterinary College laboratories.

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