Equis ISSN 2398-2977

Blood: biochemistry - lactate dehydrogenase

Synonym(s): LD, LDH, Serum LDH, SLDH

Contributor(s): Annalisa Barrelet, Kathleen P Freeman, Frank Taylor

Overview

  • Comprises 5 isoenzymes not organ specific, but useful in assessment of elevations in LDH in which the underlying cause is not apparent:
    • LD1: heart muscle, brain, testes.
    • LD2: smooth muscle, heart muscle, brain, kidney, bone and thymus.
    • LD3: all major organs and smooth muscle.
    • LD4: intestine, liver and skin.
    • LD5: skeletal muscle, skin, liver and intestine. Isosenzyme modestly elevated with liver disease   Blood biochemistry: lactate dehydrogenase - normal isoenzyme analysis   and markedly raised with skeletal myopathy.
  • Longer half-life than creatinine phosphokinase (CK or CPK)   Blood: biochemistry - creatine kinase  .

Sampling

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Tests

Methodologies

  • Enzymatic method varies between laboratories (electrophoresis needed for LDH isoenymes).

Availability

  • Limited availability.

Technique (intrinsic) limitations

  • Test results most useful when interpreted in conjunction with other laboratory results and clinical findings.

LDH without isoenzymes is so non-specific that it is rarely diagnostically useful.

Result Data

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Further Reading

Publications

Other sources of information

  • Kaneko J J, Harvey J W & Bruss M L (1997) Eds Clinical Biochemistry of Domestic Animals.5th edn. Academic Press, Boston.

Organisation(s)

  • Veterinary commercial laboratories, State diagnostic laboratories or Veterinary College laboratories.


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