Equis ISSN 2398-2977

Blood: biochemistry - glutamate dehydrogenase

Synonym(s): GLDH

Contributor(s): Annalisa Barrelet, Kathleen P Freeman, Frank Taylor

Overview

  • GLDH is a mitochondrial enzyme found mainly in liver, heart muscle and kidney. Has highest concentrations in liver so increases in blood likely related to hepatic damage.
  • The enzyme is more concentrated in the central areas of the liver lobules than in the periportal zones, so pronounced release of GLDH occurs in conditions producing contrilobular necrosis, eg ischemia, halothane toxicity.
  • Ideal:
    • With other liver enzymes in acute hepatocellular damage (necrosis).
    • With IAP elevations, is also seen in enteropathy.

Sampling

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Tests

Methodologies

  • Enzymatic method involving oxidation of NADH.

Availability

  • Variable availability. May find SDH (IDH) more commonly used in USA.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedpublished during the last 12 months.

Other sources of information

  • Barton M H & Morris D D (1998)diseases of the Liver.In: Equine Internal Medicine. Eds: Reed S M & Bayly W M. W B Saunders Co. Philadelphia. 
  • Kaneko J J, Harvey J W & Bruss M L (1997) EdsClinical Biochemistry of Domestic Animals.5th edn. Academic Press, Boston.

Organisation(s)

  • Veterinary commercial laboratories, State diagnostic laboratories or Veterinary College laboratories.


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