Equis ISSN 2398-2977

Blood: biochemistry - direct bilirubin test

Synonym(s): Conjugated bilirubin

Contributor(s): Annalisa Barrelet, Kathleen P Freeman, Frank Taylor

Overview

  • Serum bilirubin is a mixture of direct and indirect bilirubin.
  • Peripheral breakdown of red cells and myoglobin   →   uncongugated bilirubin   →   (liver) conjugated with glucuronic acid   →   excreted in bile as conjugated (direct) bilirubin.
  • Presence and degree of icterus in equine serum/plasma is difficult or impossible to evaluate maroscopically due to variable carotenoid pigments that are present, often influenced by diet.

Sampling

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Tests

Methodologies

  • Van den Bergh method.

Availability

  • Routine test, widely available.

Validity

Sensitivity

  • Van den Bergh test relatively insensitive.

Technique (intrinsic) limitations

  • Most useful when interpreted in conjunction with other laboratory and clinical findings.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Engleking L R & Paradis M R (1987) Evaluation of hepatobiliary disorders in the horse. Vet Clin North Am Equine Pract (3), 563-583.
  • Ogilvie G K, Engleking L R & Anwer M S (1985) Effects of plamsa sample storage of on blood ammonia, bilirubin and urea nitrogen concentrations - cats and horses. Am J Vet Res 46 (12), 2619-2622.

Other sources of information

  • Barton M H & Morris D D (1998) Diseases of the Liver. In: Equine Internal Medicine. Eds: S M Reed & W M Bayly. W B Saunders Co, USA.
  • Kaneko J J, Harvey J W & Bruss M L (1997) Eds. Clinical Biochemistry of Domestic Animals5th edn. Academic Press, USA.

Organisation(s)

  • Veterinary commercial laboratories, State diagnostic laboratories or Veterinary College laboratories.


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