Equis ISSN 2398-2977

Blood: biochemistry - alkaline phosphatase (SAP, ALP)

Synonym(s): ALP, Serum alkaline phosphatase, SAP

Overview

  • Number of isoenzymes produced in a range of tissues.
  • Increased serum or plasma levels are primarily derived from induction and increased release from liver and gastrointestinal tract or bone.
  • Often increased with chronic liver disease and cholestasis - increases before plasma bilirubin.
  • Enzyme catalyzing monophosphate ester hydrolysis.
  • Mitochondrial bound enzyme.
  • Variety of conditions and drugs may induce production and release.

Sampling

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Tests

Methodologies

  • Colorimetric method based on enzymatic reaction.

Availability

  • Widely available.

Technique (intrinsic) limitations

  • Test results most significant when interpreted in conjunction with other laboratory results and clinical findings.
  • May not be able to directly compare values obtained from different laboratories due to differences in methodology.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedpublished during the last 12 months.

Other sources of information

  • Barton M H & Morris D D (1998)diseases of the Liver.In: Equine Internal Medicine.Eds: Reed S M & Bayly W M. Philadelphia: W B Saunders Co.
  • Kaneko J J, Harvey J W & Bruss M L (1997) Eds Clinical Biochemistry of Domestic Animals.5th edn. Academic Press, Boston.

Organisation(s)

  • Veterinary commercial laboratories, State diagnostic laboratories or Veterinary College laboratories.


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