Equis ISSN 2398-2977

Tropicamide

Contributor(s): Sally Anne Argyle, Brian Patterson

Introduction

Name

  • Tropicamide.

Description

Chemical name

  • N-ethyl-3-hydroxy-2-phenyl-N- (pyridin-4-ylmethyl) propanamide.

Molecular formula

  • C17 H20 N2 O2 .

Molecular weight

  • 284.35.

Physical properties

  • Topical eye drop.

Storage requirements

  • Depends on the specific preparation, eg:
    • Mydriacyl 0.5%:
      • Do not store >25°C.
      • Do not refrigerate or freeze.
      • Keep container in the outer carton.
      • Keep container tightly closed.
      • Discard contents 4 weeks after opening.
    • Minims 0.5% and 1% tropicamide:
      • Store <25°C.
      • Do not freeze.
      • Protect from light.

Uses

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Indications

  • Detailed examination of the crystalline lens, vitreous and retina.
  • Used therapeutically to avoid the formation of posterior synechiae by maintaining a mobile pupil.
  • Atropine   Atropine sulfate   is the preferred medication to achieve cycloplegia in cases of uveitis   Uveitis: anterior - overview  .
  • See also Therapeutics: eye    Therapeutics: eye  .

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • None reported.

with diagnostic tests

  • Tropicamide has been reported to decrease Schrimer Tear Test values for several hours following application in horses.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Selk Ghaffari M, Sabzevari A, Radmehr B (2009)Effect of topical 1% tropicamide on Schirmer tear test results in clinically normal horses.Vet Ophthal12(6), 369-371PubMed.
  • Gelatt K N, Gum G G & Mackay E (1995)Evaluation of mydriatics in horses.Vet Comp Ophthal5, 104107.

Other sources of information

  • Matthews A (2004)Ophthalmic Therapeutics.In:Equine Clinical Pharmacology. Eds: Bertone J & Horspool L. pp 217-246.
  • Report a Suspect Adverse Reaction.Veterinary Medicines Directorate. Website:www.vmd.defra.gov.uk/adversereactionreporting.

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