ISSN 2398-2977      

Sotalol

pequis
Contributor(s):

Vetstream Ltd

Romain Pariaut


Introduction

Name

  • Sotalol.

Class of drug

  • Anti-arrhythmic.
  • A non-selective ß-adrenergic blocking drug with potassium channel blocking effects.
  • Classified as type III anti-arrhythmic under the Vaughan Williams classification.

Description

Chemical name

  • Sotalol HCl (racemic mixture of d- and l-stereo-isomers).

Molecular formula

  • C12H20N2O3S.

Molecular weight

  • 272.37 g/mol.

Physical properties

  • White crystalline solid.
  • Soluble in water.

Storage requirements

  • Store at room temperature.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Sympathomimetics may have their effects blocked by the drug.
  • Negative ionotropic drugs (calcium channel blockers and beta blockers Esmolol) may have an additive negative ionotropic effect with sotalol.
  • Hypotensive agents (eg vasodilators, diuretics Therapeutics: cardiovascular system, phenothiazines Acepromazine, anti-hypertensive drugs) may increase the hypotensive effects of sotalol.
  • Myocardial depressants (anesthetics) may exacerbate the myocardial depressant effects of sotalol.
  • Administration with amiodarone may increase the pro-arrhythmic effect of the drug via excessive prolongation of repolarization.
  • Sotalol may prolong the hypoglycemic Hypoglycemia effects of insulin therapy.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Opie L & Gersh B (2013) Drugs for the Heart. 8th edn. Saunders, USA.
  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
  • US Food & Drug Administration (FDA) Questions and Answers on FDA's Adverse Event Reporting System (FAERS). Website: www.fda.gov.
  • Veterinary Medicines Directorate. Adverse Reaction Reporting. Website: www.vmd.defra.gov.uk.
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