ISSN 2398-2977      

Sevoflurane

pequis

Introduction

Name

  • Sevoflurane.

Class of drug

  • Inhalational anesthetic.

Description

Chemical name

  • Fluoromethyl 2,2,2 trifluoro-1-(trifluoromethyl) ethyl ether.

Molecular formula

  • C4H3F7O.

Storage requirements

  • Stored in plastic bottles with a filling attachment specific to sevoflurane vaporizers.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • Lower doses of sevoflurane are required in premedicated patients and during concurrent nitrous oxide administration.
  • Sevoflurane affects the intensity and duration of neuromuscular block produced by non-depolarizing muscle relaxants.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Gazalo-Marcilla M et al (2013) Effects of a constant-rate infusion of dexmedetomidine on the minimal alveolar concentration of sevoflurane in ponies. Equine Vet J 45 (2), 204-208 PubMed.
  • Valverde A, Gunkelt C, Doherty T J, Giguere S & Pollak A S (2005) Effect of a constant rate infusion of lidocaine on the quality of recovery from sevoflurane or isoflurane general anaesthesia in horses. Equine Vet J 37 (6), 559-564 PubMed.
  • Steffey E P, Mama K R, Galey F D, Puschner B & Woliner M J (2005) Effects of sevoflurane dose and mode of ventilation on cardiopulmonary function and blood biochemical variables in horses. Am J Vet Res 66 (4), 606-614 PubMed.
  • Kushiro T et al (2005) Anesthetic and cardiovascular effects of balanced anesthesia using constant rate infusion of midazolam-ketamine-medetomidine with inhalation of oxygen-sevoflurane (MKM-OS anesthesia) in horses. J Vet Med Sci 67 (4), 379-384 PubMed.
  • Yamashita K et al (2005) Infusion of guaifenesin, ketamine and medetomidine in combination with inhalation of sevoflurane versus inhalation of sevoflurane alone for anesthesia of horses. JAVMA 221 (8), 1150-1155 PubMed.
  • Steffey E P (2002) Recent advances in inhalation anesthesia. Vet Clin North Am Equine Pract 18 (1), 159-168 PubMed.

Other sources of information

  • Matthews N S (2001) How to Use Sevoflurane Anesthesia in Horses. In: AAEP Proc Vol 47. pp 426-427.
  • Hall L W, Clarke K W & Trim C M (2001) Veterinary Anaesthesia. 10th edn. W B Saunders.
  • NOAH (2005) NOAH Compendium of Data Sheets for Animal Medicines -www.noahcompendium.co.uk.
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