ISSN 2398-2977      

Salbutamol sulfate

pequis

Synonym(s): Albuterol sulfate


Introduction

Name

  • Salbutamol sulfate (INN).
  • Albuterol sulfate (USAN).

Class of drug

  • Non-catecholamine ß-adrenergic agonist.

Description

Chemical name

  • alpha1-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-alpha, alpha'-diol sulfate.

Molecular formula

  • (CH13 H21 NO3 )2 "H2 SO4 .

Molecular weight

  • 576.70 g.

Physical properties

  • Microcrystallien inhaled suspension.
  • Pressurized aluminium canister with a metered valve supplied with a plastic actuator (inhaler).

Storage requirements

  • Store at 25°C.
  • Do not expose to excessive heat.
  • Do not pierce the canister, even when empty.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Bailey J, Robertson S, Pablo L et al (2011) Effect of an inhaled beta 2 adrenergic agonist on arterial partial pressure of oxygen in hypoxemic anaesthetised horses. Vet Anaes & Analg 28 (2) 97-110.
  • Coruzzi G et al (1989) Effect of calcium-channel blockers and salbutamol on the isolated mare uterus - interaction with the calcium agonist Bay K 8644. J Vet Pharmacol & Therap 12 (4), 404-410 PubMed.
  • Derksen F J et al (1999) Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction. Am J Vet Res 60 (6), 689-693 PubMed.
  • Mazan M R & Hoffman A M (2001) Effects of aerosolized albuterol on physiologic responses to exercise in Standardbreds. Am J Vet Res 62 (11), 1812-1817 PubMed
  • Patschova M et al (2010) The effects of inhalation salbutamol administration on systemic and pulmonary haemodynamic, pulmonary mechanics and oxygen balance during general anaesthesia in the horse. Vet Medicina 55 (9), 445-456.
  • Robertson S A & Bailey J E (2002) Aerosolized salbutamol (albuterol) improves PaO2 in hypoxaemic anaesthetized horses-a prospective clinical trial in 81 horses. Vet Anaes & Analg 29 (4), 212-218.

Other sources of information

  • Glaxo Wellcome (2009) Ventolin" Evohaler" 100 micrograms. Package Leaflet: Information for the User.
  • Mazan M R et al (2005) Salbutamol inhalation does not modify airway hyper-reactivity in the horse. In: Proc 51st Annual AAEP Convention. Seattle, Washington, USA. pp 49-51.

Organisation(s)

  • British Racing Authority, 75 High Holborn, London WC1V 6LS, UK. Tel: +44 (0)207 152 0000; Email: info@britishhorseracing.com; Website: www.britishhorseracing.com.
  • Fédération Equestre Internationale, HM King Hussein I Building, Chemin de la Joliette 8, 1006 Lausanne, Switzerland. Tel: +41 21 3104747; Website: www.fei.org.

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