Equis ISSN 2398-2977

Salbutamol sulfate

Synonym(s): Albuterol sulfate

Contributor(s): Adam Auckburally, Eleanor Holden

Introduction

Name

  • Salbutamol sulfate (INN).
  • Albuterol sulfate (USAN).

Class of drug

  • Non-catecholamine ß-adrenergic agonist.

Description

Chemical name

  • alpha1-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-alpha, alpha'-diol sulfate.

Molecular formula

  • (CH13 H21 NO3 )2 "H2 SO4 .

Molecular weight

  • 576.70 g.

Physical properties

  • Microcrystallien inhaled suspension.
  • Pressurized aluminium canister with a metered valve supplied with a plastic actuator (inhaler).

Storage requirements

  • Store at 25°C.
  • Do not expose to excessive heat.
  • Do not pierce the canister, even when empty.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Bailey J, Robertson S, Pablo Let al(2011)Effect of an inhaled beta 2 adrenergic agonist on arterial partial pressure of oxygen in hypoxemic anaesthetised horses.Vet Anaes & Analg28(2) 97-110.
  • Coruzzi Get al(1989)Effect of calcium-channel blockers and salbutamol on the isolated mare uterus - interaction with the calcium agonist Bay K 8644.J Vet Pharmacol & Therap12(4), 404-410PubMed.
  • Derksen F Jet al(1999)Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction.Am J Vet Res60(6), 689-693PubMed.
  • Mazan M R & Hoffman A M (2001)Effects of aerosolized albuterol on physiologic responses to exercise in Standardbreds.Am J Vet Res62(11), 1812-1817PubMed
  • Patschova Met al(2010)The effects of inhalation salbutamol administration on systemic and pulmonary haemodynamic, pulmonary mechanics and oxygen balance during general anaesthesia in the horse.Vet Medicina55(9), 445-456.
  • Robertson S A & Bailey J E (2002)Aerosolized salbutamol (albuterol) improves PaO2 in hypoxaemic anaesthetized horses-a prospective clinical trial in 81 horses.Vet Anaes & Analg29(4), 212-218.

Other sources of information

Organisation(s)

  • British Racing Authority, 75 High Holborn, London WC1V 6LS, UK. Tel: +44 (0)207 152 0000; Email:  info@britishhorseracing.com ; Website:  www.britishhorseracing.com .
  • Fédération Equestre Internationale, HM King Hussein I Building, Chemin de la Joliette 8, 1006 Lausanne, Switzerland. Tel: +41 21 3104747; Website:  www.fei.org .

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