Equis ISSN 2398-2977

Quinidine

Contributor(s): Lesley Young

Introduction

Name

  • Quinidine sulfate (powder for oral administration).
  • Quinidine gluconate (solution for IV administration - not available in the UK).

Class of drug

  • Class Ia anti-arrhythmic.

Uses

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Indications

  • Primarily used to restore normal sinus rhythm to cases of sustained atrial fibrillation    Heart: atrial fibrillation  .
  • Also indicated for the treatment of other re-entrant supraventricular and ventricular arrhythmias.

Administration

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Precautions

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Interactions

with other drugs

  • Cardiac glycosides: enhanced effect of digoxin   Digoxin   - doubling of steady-state plasma levels.
  • Cimetidine   Cimetidine  : increased plasma-quinidine concentrations.
  • Diuretics: toxicity increased by hyperkalemia with loop and thiazide diuretics.
  • Warfarin   Warfarin sodium  : enhanced anticoagulant effect.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Ohmura H, Hiraga A, Aida H, Kawahara M & Tsubone H (2003)Influence of quinidine and flecainide on autonomic nervous acitivity in Thoroughbred horses.Vet Rec152(4), 114-116PubMed.
  • Reef V B, Reimer J M & Spencer P A (1995)Treatment of atrial fibrillation in horses: new perspectives.J Vet Intern Med9(2), 57-67PubMed.
  • Muir W W III, Reed S M & McGuirk S M (1990)Treatment of atrial fibrillation in horses by intravenous administration of quinidine.JAVMA197(12), 1607-1610PubMed.
  • Reef V B, Levitan C W & Spencer P A (1988)Factors affecting prognosis and conversion in equine atrial fibrillation.J Vet Intern Med2(1), 1-6PubMed.
  • Muir W W & McGuirk S M (1985)Pharmacology and pharmacokinetics of drugs used to treat cardiac disease in horses.Vet Clin North Am Equine Pract1(2), 335-352PubMed.
  • McGuirk S M & Muir W W (1985)Diagnosis and treatment of cardiac arrhythmias.Vet Clin North Am Equine Pract1(2), 353-370PubMed.

Other sources of information

  • Derived fromThe Veterinary Formulary4th edn (1998) Bishop, Y (Ed.). British Veterinary Association and Royal Pharmaceutical Society.

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