ISSN 2398-2977      

Propanolol

pequis
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Introduction

Name

  • Propranolol hydrochloride.

Class of drug

  • Non-selective beta blocker, acts both as beta-1 and beta-2 adrenoceptors.
  • Antiarrhythmic.
  • Vaughan-Williams classification II.

Description

Chemical name

  • (RS)-1-[(1-Methylethylamino]-3-(1-naphthalenyloxy)-2-propanol hydrochloride.

Molecular formula

  • C16H21NO2"HCl.

Molecular weight

  • 295.80 g.

Physical properties

  • Clear, colorless, aqueous solution.
  • White, odorless, crystalline powder.

Storage requirements

  • Store at room temperature.

Uses

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Indications

  • In the horse it is suggested as a treatment of supraventricular and ventricular tachycardia when other therapeutic agents have proven refractory.
  • Used in the treatment of rhythm disturbances associated with automaticity or re-entry.
  • May be useful in the treatment of arrhythmias associated with the administration of halogenated anesthetic agents.
  • Propranolol is rarely first line treatment.
  • Can be used for the treatment of quinidine-induced ventricular tachyarrhythmias.
  • Many other indications in humans.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • No reported drug interactions in the horse.
  • Cimetidine   Cimetidine  increases plasma concentrations of propranolol in humans.
  • May enhance effects of hypotensive drugs.
  • Actions of sympathomimetics may have their beta-receptor actions blocked.
  • Care with mixed alpha and beta sympathomimetics as alpha effects of drugs such as epinephrine   Epinephrine  (adrenaline) will be unopposed and lead to rapid increases in blood pressure.
  • Lidocaine   Lidocaine   clearance may be impaired by propranolol.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Aramaki S et al (2000) Pharmacokinetics of propranolol and its metabolites in horses after intravenous or oral administration. Biol & Pharma Bulletin 23 (11), 1333-1340 PubMed
  • Ingarden J, Dubiel A & Rauluszkiewicz S (1998) The effect of administration of a beta blocker in periparturient mares. Equine Vet J Suppl 19-20 PubMed.
  • Baggot J D (1995) The Pharmacological basis of cardiac drug selection for use in horses. Equine Vet J Suppl 27 (19), 97-100 PubMed.
  • Muir W W & McGuirk S (1987) Cardiovascular drugs: their pharmacology and use in the horse. Vet Clin North Am Equine Pract (1), 37-57 VetMedResource.
  • Branch R A et al (1973) The reduction of lidocaine clearance by dl-propranolol: an example of hemodynamic drug interaction. J Pharmacol Exp Ther 184 (2), 515-519 PubMed.

Other sources of information

  • Sage A & Mogg T D (2010) Pharmacology of Drugs Used to Treat Cardiac Disease. In: Cardiology of the Horse. 2nd edn. Eds: Marr C M & Bowen I M. Saunders Elsevier. pp 75-87.
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