Equis ISSN 2398-2977

Procainamide

Contributor(s): Adam Auckburally, Eleanor Holden

Introduction

Name

  • Procainamide hydrochloride.

Class of drug

  • Sodium channel blocker.
  • Anti-arrhythmic.
  • Vaughn Williams Classification 1a.

Description

Chemical name

  • p-amino-N-[2-(diethylamino)ethyl]-benzamide monohydrochloride.

Molecular formula

  • C13H21N3O"HCl.

Molecular weight

  • 271.79 g.

Physical properties

  • Clear, colorless, aqueous solution.
  • White, odorless, crystalline powder.

Storage requirements

  • Store at room temperature.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmacokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

  • No reported drug interactions in the horse.
  • Cimetidine   Cimetidine   increases plasma concentrations of procainamide in humans.
  • May enhance effects of hypotensive drugs.
  • Effect may be additive if quinidine   Quinidine  has been administered.
  • In contrast to quinidine, when procainamide is co-administered with digoxin   Digoxin  , elevated plasma levels of digoxin do not occur. Therefore it may be a safer drug to administer to horses currently receiving digoxin.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ellis E J et al (1994) The pharmacokinetics and pharmacodynamics of procainamide  in horses after intravenous administration. J Vet Pharmacol Therap 17 (4), 265-270 PubMed.
  • Papich M G et al (1986) Pharmacokinetics of procainamide hydrochloride in dogs. Am J Vet Res 47 (11), 2351-2358.
  • Muir W W & McGuirk S (1985) Cardiovascular drugs. Their pharmacology and use in the horse. Vet Clin North Am Equine Pract (1), 37-57.

Other sources of information

  • Miller M W & Adams H R (2009) Antiarrthymic Agents. In: Veterinary Pharamcology & Therapeutics. 9th edn. Eds: Riviere J E & Papich M G. Wiley-Blackwell, US. pp 541-574.
  • Kimberley M & McGurrin J (2006) Update on Antiarrhythmic Therapy in Horses. In: The 24th Annual Forum of the American College of Veterinary Internal Medicine.

ADDED