ISSN 2398-2977      

Polymixin B Sulfate

pequis
Contributor(s):

Sally Anne Argyle


Introduction

Name

  • Polymixin B Sulfate.

Class of drug

  • Cationic antimicrobial.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • Primarily used topically, eg superficial ocular infections.
  • Polymixin B-sensitive infections: Gram-negative bacterial infections, egPseudomonas aerginosa.
  • Use has also been advocated for the treatment of endotoxemia in the horse using a low dose of polymixin B administered IV. The dose employed is considered suboptimal for bactericidal activity and toxicity is reduced   Endotoxemia: treatment  .

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

Antibacterial agents
  • Acts synergistically with a number of other antibacterial agents because enhances penetration by disrupting outer cell membrane.

Cationic detergents

  • Potentiate antibacterial effects of Polymixin B againstPseudomonas aeruginosa  Pseudomonas aeruginosa  , eg chlorhexidine.

Chelating agents

  • Potentiate antibacterial effects of Polymixin B againstPseudomonas aeruginosa  Pseudomonas aeruginosa  , eg EDTA.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Moore J N & Barton M H (2003) Treatment of endotoxemia. Vet Clin North Am Eq Pract 19 (3), 681-695 PubMed.

Other sources of information

  • Derived from The Veterinary Formulary (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.
  • Bertone J & Horspool L (2004) Eds. Equine Clinical Pharmacology. Saunders. ISBN: 0702024848.
  • Derived from Antimicrobial Therapy (2000) 3rd edn. Eds: Prescott J F, Baggot J D, Walker R D. Iowa State University Press.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code