Equis ISSN 2398-2977

Polymixin B Sulfate

Contributor(s): Sally Anne Argyle

Introduction

Name

  • Polymixin B Sulfate.

Class of drug

  • Cationic antimicrobial.

Uses

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Indications

  • Primarily used topically, eg superficial ocular infections.
  • Polymixin B-sensitive infections: Gram-negative bacterial infections, egPseudomonas aerginosa.
  • Use has also been advocated for the treatment of endotoxemia in the horse using a low dose of polymixin B administered IV. The dose employed is considered suboptimal for bactericidal activity and toxicity is reduced   Endotoxemia: treatment  .

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Antibacterial agents
  • Acts synergistically with a number of other antibacterial agents because enhances penetration by disrupting outer cell membrane.

Cationic detergents

  • Potentiate antibacterial effects of Polymixin B againstPseudomonas aeruginosa  Pseudomonas aeruginosa  , eg chlorhexidine.

Chelating agents

  • Potentiate antibacterial effects of Polymixin B againstPseudomonas aeruginosa  Pseudomonas aeruginosa  , eg EDTA.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedpublished during the last 12 months.
  • Moore J N & Barton M H (2003)Treatment of endotoxemia.Vet Clin North Am Eq Pract19(3), 681-695PubMed.

Other sources of information

  • Derived fromThe Veterinary Formulary. (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.
  • Bertone J & Horspool L (2004) EdsEquine Clinical Pharmacology. Saunders. ISBN: 0702024848.
  • Derived fromAntimicrobial Therapy. (2000) 3rd edn. Eds: Prescott J F, Baggot J D, Walker R D. Iowa State University Press.

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