Equis ISSN 2398-2977

Phenytoin

Introduction

Name

  • Phenytoin.

Class of drug

  • Anticonvulsant.

Description

Chemical name

  • Phenytoin sodium.
  • 5,5-diphenyl-2,4-imidazolidinedione.

Molecular formula

  • C15H12N2O2.

Physical properties

  • Capsules.
  • Suspension.
  • Tablets.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs


Many interactions are reported in the human literature. This list includes only those which may be of veterinary significance.

Drugs increasing plasma concentration of phenytoin

Drugs decreasing effect of phenytoin (absorption, effects or plasma concentration)

  • Antacids.
  • Antineoplastic drugs.
  • Barbiturates.
  • Calcium.
  • Nitrofurantoin.
  • Pyridoxine.

Drugs affected by phenytoin (increased metabolizm)

Pethidine

  • The analgesic properties may be reduced by phenytoin whereas the toxic effects may be enhanced   Pethidine  .

Antiepileptics

  • Concomitant administration of 2 or more antiepileptics may enhance toxicity without a corresponding increase in antiepileptic effect.

with diagnostic tests

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.
  • Knottenbelt D K (1997) In: Formulary of Equine Medicine. Liverpool University Press, UK. ISBN 0-85323-740-9.

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