Equis ISSN 2398-2977

Phenylephrine

Contributor(s): Adam Auckburally, Joanne Michou

Introduction

Name

  • Phenylephrine HCl.

Class of drug

  • Sympathomimetic.
  • Alpha-1 agonist.

Description

Chemical name

  • (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol.

Molecular formula

  • C9H13NO2.

Molecular weight

  • 167.205 g.

Physical properties

  • Colorless aqueous solution.

Storage requirements

  • Room temperature.
  • Protect from light.

Uses

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Indications

  • Hypotension as a result of vasodilation (reduced total peripheral resistance, eg endotoxemia   Endotoxemia: overview  ).
  • Treatment of vasodilation associated with the administration of alpha-1 antagonists, eg acepromazine   Cyclosporine  .
  • Support of blood pressure following epidural administration of local anesthetics   Anesthesia: local - overview  .
  • Reduction of a nephrosplenic entrapment.
  • Diagnosis of grass sickness   Grass sickness   by instillation of 0.5% solution into the conjunctiva of one eye.

Ensure adequate volume resuscitation prior to administration of phenylephrine. Phenylephrine is NOT a substitute for volume replacement.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Can be used in combination with other sympathomimetics, eg dobutamine   Dobutamine  , but intensive monitoring is recommended.
  • Monoamine oxidase inhibitors will markedly prolong action - use smaller doses.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Hardy J, Minton M, Robertson J T, Beard W L & Beard L A (2000) Nephrosplenic entrapment in the horse: A retrospective study of 174 cases. Equine Vet J 32 (S32), 95-97 PubMed.
  • Hahn C N & Mayhew I G (2000) Phenylephrine eyedrops as a diagnostic test in equine grass sickness. Vet Rec 147, 603-606 PubMed.

Other sources of information

  • Peck T E, Hill S A & Williams M (2005) Analgesics. In: Pharmacology for Anaesthesia and Intensive Care. Greenwich Medical Media, UK. pp 123-148.

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