Equis ISSN 2398-2977

Penicillin G

Synonym(s): Benzylpenicillin, procaine penicillin G, penicillin G procaine

Contributor(s): Sally Anne Argyle

Introduction

Name

  • Penicillin G.

Class of drug

Description

Chemical name

  • [2S-(2-alpha,5-alpha,6-beta)]-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Molecular formula

  • C16H18N2O4S.

Physical properties

  • Sterile powder.
  • Sterile, aqueous suspension.

Storage requirements

  • Powder:
    • <25°C.
  • Suspension:
    • Between 2-8°C.
    • Do not store in freezer.
    • Protect from light.

Uses

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Indications

  • Penicillin-sensitive infections.
  • Primary Gram-positive organisms but not beta-lactamase producing.
  • A drug of choice for the management of streptococcal infections in the horse.
  • Strangles   Strangles (Streptococcus equi infection)  caused byStreptococcus equi.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Synergistic with the beta-lactam antibacterials.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedpublished during the last 12 months.
  • Widmer A, Kummer M, Wehrli Eser M & Furst A (2009)Comparison of the clinical efficacy of cefquinome with the combination of penicillin G and gentamicin in equine patients.Equine Vet Educ21(8), 430-435.
  • Murchie T Aet al(2006)Continuous monitoring of penicillin G and gentamicin in allantoic fluid of pregnant pony mares byin vitromicrodialysis.Equine Vet J38(6), 520-525.
  • Gustafsson Aet al(2004)Study of fecal shedding of Clostridium difficile in horses treated with penicillin.Equine Vet J36(2), 180-182PubMed.
  • Horspool L J & McKellar Q A (1995)Disposition of penicillin G sodium following intravenous and oral administration to Equidae.Br Vet J151(4), 401-412PubMed.

Other sources of information

  • Bertone J & Horspool L (2004) EdsEquine Clinical Pharmacology. Saunders. ISBN: 0702024848.
  • Derived fromThe Veterinary Formulary. (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.
  • Prescott J F, Baggot J D & Walker R D (2000) EdsAntimicrobial Therapy in Veterinary Medicine.3rd edn. Iowa State University Press.

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