Equis ISSN 2398-2977

Midazolam

Contributor(s): Cody Coyne, Mark Senior

Introduction

Name

  • Midazolam.

Class of drug

  • Benzodiazepine (intravenous anesthetic   Anesthesia: intravenous (IV)  ):
    • Alprazolam, chlordiazepam, chlorazepam, diazepam   Diazepam  , halazepam, lorazepam, midazolam, oxazepam, prazepam.

Description

Chemical name

  • 8-chloro-6-(2(fluoro-phenyl)-methyl-4H-imidazol[1,5-a][1,4]benzodiazepine hydrochloride.

Molecular formula

  • C18H13ClFN3 HCl.

Molecular weight

  • 362.25.

Physical properties

  • White to light yellow crystals insoluble in water, but hydrochloric salt is water soluble.

Uses

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Indications

  • Control of seizure activity as a substitute for barbiturates, particularly in premature or term neonatal foals admitted to ICU units.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Physostigmine - antagonist properties related to anticholinesterase inhibition.
  • Aminophylline - accelerates recovery from CNS depression exerted by diazepam.
  • Central nervous system depressants will enhance the sedation effect of midazolam.
  • Inhibitors of cytochrome P450-3A4, including cimetadine (not ranitidine), erythromycin, diltiazem, verapamil, ketoconazole and itraconazole can promote prolongation of sedative effects due to decreased metabolism of the parent compound.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedandVetMedResource.
  • Hubbell J A Eet al(2013)Pharmacokinetics of midazolam after intravenous administration to horses.Equine Vet J45(6), 721-725PubMed.

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