Equis ISSN 2398-2977

Metronidazole

Contributor(s): Sally Anne Argyle

Introduction

Name

  • Metronidazole.

Class of drug

Description

Chemical name

  • 2-methyl-5-nitroimidazole-1-ethanol.

Molecular formula

  • C6H9N3O3.

Physical properties

  • Sterile, aqueous solution.
  • Tablets.

Storage requirements

  • Protect from light.
  • <25°C.

Uses

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Indications

  • Infections caused by anaerobic bacteria.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Metronidazole is often used in combination with other antimicrobials.
  • Rational choices would include which have activity against aerobic organisms   Therapeutics: antimicrobials  .
  • Cimetidine   Cimetidine  - increased plasma-metronidazole concentration.
  • Phenobarbital   Phenobarbital  - increased metabolism of metronidazole.
  • Phenytoin - reduced phenytoin metabolism.
  • Warfarin   Warfarin sodium  - enhanced anticoagulant effect.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedpublished during the last 12 months.
  • McGorum, B C, Dixon, P M & Smith, D G (1998)Use of metronidazole in equine acute idiopathic toxaemic colitis.Vet Rec142(23), 635-638PubMed.

Other sources of information

  • Bertone J & Horspool L (2004) EdsEquine Clinical Pharmacology. Saunders. ISBN: 0702024848.
  • Derived fromThe Veterinary Formulary. (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.

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