Equis ISSN 2398-2977

Ketamine hydrochloride

Contributor(s): Mark Senior

Introduction

Name

  • Ketamine hydrochloride.

Class of drug

  • Dissociative anesthetic.

Description

Chemical name

  • (+/-)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone.

Molecular formula

  • C13H16ClNO.

Physical properties

  • Clear solution.

Storage requirements

  • In a locked cabinet.
  • <25°C.
  • Protect from light.

Uses

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Indications

  • Induction of general anesthesia, in combination with detomidine, romifidine or xylazine.
  • Maintenance of general anethesia as part of a Total Intravenous Anesthetic protocol.

Administration

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Villalba M, Santiago I & Gomex de Segura I A (2011) Effects of constant rate infusion of lidocaine and ketamine, with or without morphine, on isoflurane MAC in horses. Equine Vet J 43 (6), 721-726 PubMed.
  • Benredouane K, Ringer S K, Fourel I et al (2011) Comparison of xylazine-butrophanol and xylazine-morphine-ketamine infusions in horses undergoing a standing surgery. Vet Rec 169 (14), 364 PubMed.
  • Sinclair M & Valverde A (2009) Short-term anaeshtesia with xylazine, diazepam/ketamine for castration in horses under field conditions: Use of intravenous lidocaine. Equine Vet J 41 (2), 149-152 PubMed.
  • Freeman S L et al (2000) Cardiopulmonary effects of romifidine and detomidine used as premedicants for ketamine/halothane anaesthesia in ponies. Vet Rec 147, 535-539 PubMed.

Other sources of information

  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.

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