Equis ISSN 2398-2977

Ketamine hydrochloride

Contributor(s): Mark Senior

Introduction

Name

  • Ketamine hydrochloride.

Class of drug

  • Dissociative anesthetic.

Description

Chemical name

  • (+/-)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone.

Molecular formula

  • C13H16ClNO.

Physical properties

  • Clear solution.

Storage requirements

  • In a locked cabinet.
  • <25°C.
  • Protect from light.

Uses

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Indications

  • Induction of general anesthesia, in combination with detomidine, romifidine or xylazine.
  • Maintenance of general anethesia as part of a Total Intravenous Anesthetic protocol.

Administration

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Pharmocokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Villalba M, Santiago I & Gomex de Segura I A (2011)Effects of constant rate infusion of lidocaine and ketamine, with or without morphine, on isoflurane MAC in horses.Equine Vet J43(6), 721-726PubMed.
  • Benredouane K, Ringer S K, Fourel I, Lepage O M, Portier K G & Bettschart-Wolfensberger R (2011)Comparison of xylazine-butrophanol and xylazine-morphine-ketamine infusions in horses undergoing a standing surgery.Vet Rec169(14), 364PubMed.
  • Sinclair M & Valverde A (2009)Short-term anaeshtesia with xylazine, diazepam/ketamine for castration in horses under field conditions: Use of intravenous lidocaine.Equine Vet J41(2), 149-152PubMed.
  • Freeman S Let al(2000)Cardiopulmonary effects of romifidine and detomidine used as premedicants for ketamine/halothane anaesthesia in ponies.Vet Rec147, 535-539PubMed.

Other sources of information

  • Derived fromThe Veterinary Formulary4th edn (1998) Bishop, Y (Ed.). British Veterinary Association and Royal Pharmaceutical Society.

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