Equis ISSN 2398-2977

Isoflurane

Contributor(s): Mark Senior, Vetstream Ltd

Introduction

Name

  • Isoflurane.
It was recently announced that the third-party manufacturer of isoflurane had to cease production with immediate effect, resulting in a shortfall of the anesthetic. Stocks of alternative products are believed to be limited, with the potential for supply to be restricted. However, it has now been announced that BEVA, BSAVA and the AVA have successfully engaged with the VMD to facilitate a practical solution to the isoflurane supply problem. Click here for further information!

Class of drug

  • Inhalational anesthetic.

Description

Chemical name

  • 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane.
  • 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether.

Molecular formula

  • C3H2ClF5O.

Physical properties

  • Pungent ethereal odor.
  • Non-flammable.
  • Non-explosive.

Storage requirements

  • <25°C.
  • Store away from direct heat and sunlight.
  • In original tight container.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Villalba M, Santiago I & Gomex de Segura I A (2011)Effects of constant rate infusion of lidocaine and ketamine, with or without morphine, on isoflurane MAC in horses.Equine Vet J43(6), 721-726PubMed.
  • Valverde A et al(2010)Comparison of cardiovascular function and quality of recovery in isoflurane-anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery.Equine Vet J42(3), 192-199PubMed.
  • Raisis A Let al(2000)A comparison of the haemodynamic effects of isoflurane and halothane anaesthesia in horses.Equine Vet J32(4), 318-326PubMed.

Other sources of information

  • Derived fromThe Veterinary Formulary4th edn (1998) Bishop, Y (Ed.). British Veterinary Association and Royal Pharmaceutical Society.

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