Equis ISSN 2398-2977

Imipramine

Synonym(s): Tofranil, Melipramine

Contributor(s): Graham Munroe, Carla Sommardahl

Introduction

Name

  • Imipramine hydrochloride.

Class of drug

  • Tricyclic antidepressant drug (TCA) which is a phenothiazine analog and has a number of effects throughout the central nervous system.
  • Used in man for the treatment of major depression and bed wetting in children.

Description

Chemical name

  • Imipramine hydrochloride.

Molecular formula

  • C19H24N2.

Molecular weight

  • 280.407 g/mol.

Physical properties

  • Available as imipramine hydrochloride oral paste from Wedgwood Pharmacy in the USA in two dose strengths: 50 mg/ml and 200 mg/ml.
  • Tablets: 25 mg.
  • Capsules.
  • Oral oil suspension.
  • Intravenous form.

Storage requirements

  • Text here

Uses

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Indications

  • Ejaculatory dysfunction in breeding stallions Male: ejaculatory dysfunction.
  • Narcolepsy and other sleep disorders CNS: narcolepsy/cataplexy with variable success. It appears more effective in controlling the cataplexy component of narcolepsy rather than the sleepiness part.
  • Equine self-mutilation syndrome Behavior: self-mutilation has been treated successfully using this drug at 1 mg/kg every 12 hours, and also in decreasing the anxiety in stallions during breeding Behavior: stallion.
  • It has been suggested as a possible treatment for urospermia Semen: urosemen in the stallion but there is little evidence of its success within the published literature.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • Should not be used in animals also receiving MAO inhibitors as it can cause severe increases in blood pressure and sudden death.
  • May also interact with drugs that inhibit the CYP450 enzyme as the TCAs act as substrates for this enzyme. The combination may markedly increase the serum levels of the TCAs.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • McDonnell S M (2001) Oral imipramine and intravenous xylazine for pharmacologically-induced ex copula ejaculation in stallions. Anim Reprod Sci 68 (3-4), 153-159 PubMed.
  • Peck K E et al (2001) Pharmacokinetics of imipramine in narcoleptic horses. Am J Vet Res 62 (5), 783-786 PubMed.
  • Turner R M et al (1995) Use of imipramine hydrochloride for treatment of urospermia in a stallion with a dysfunctional bladder. JAVMA 207 (12), 1602-1606 PubMed.

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