Equis ISSN 2398-2977

Halothane

Contributor(s): Adam Auckburally, Mark Senior, Vetstream Ltd

Introduction

Name

  • Halothane.

Currently unavailable.

Removed from the EU Essential List of Drugs for food-producing horses.

Class of drug

  • Inhalation anesthetic.

Description

Chemical name

  • 2-bromo-2-chloro-1,1,1-trifluoroethane.

Molecular formula

  • C2HBrCIF3.

Molecular weight

  • 197.381 g.

Physical properties

  • Liquid at room temperature.
  • Non-flammable, non-explosive.

Storage requirements

  • Unstable in light.
  • Stored in dark brown bottles.
  • Stabilizing agent 0.01% thymol - vaporizers should be serviced regularly as deposits of thymol can cause inaccurate delivery and effect vaporizer function.

Uses

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Indications

  • Inhalational anesthesia.

Do not mix with

  • Administer as a sole volatile agent vaporized in a carrier gas (oxygen or oxygen:air mixtures).

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Dysrhythmias may develop with the concurrent use of sympathomimetic agents.
  • Halothane requirement is reduced if used as part of a balanced anesthetic technique, eg following the administration of acepromazine   Cyclosporine  or alpha-2 agonists.

with diagnostic tests

  • Elevations in hepatic-derived may be elevated following administration of halothane.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Aleman M, Brosnan R Jet al (2005)Malignant hyperthermia in a horse anesthetized with halothane.J Vet Intern Med19(3), 363-367PubMed.
  • Freeman S Let al(2000)Cardiopulmonary effects of romifidine and detomidine used as premedicants for ketamine/halothane anaesthesia in ponies.Vet Rec147, 535-539PubMed.
  • Raisis A Let al(2000)A comparison of the haemodynamic effects of isoflurane and halothane anaesthesia in horses.Equine Vet J32(4), 318-326PubMed.

Other sources of information

  • Steffey E P (2009)Inhalational Anesthetics and Gases.In:Equine Anesthesia: Monitoring & Emergency Therapy. 2nd edn. Eds: Muir W W & Hubbell J A E. Saunders Elsevier, London, UK. pp 288-314.
  • Derived fromThe Veterinary Formulary.4th edn (1998) Bishop, Y (Ed.). British Veterinary Association and Royal Pharmaceutical Society.

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