Equis ISSN 2398-2977

Gentamicin

Contributor(s): Sally Anne Argyle, Cody Coyne, Graham Munroe

Introduction

Name

  • Gentamicin.

Class of drug

Description

Chemical name

  • Gentamicin.

Physical properties

  • Sterile aqueous solution.
  • Sterile viscous solution.

Storage requirements

  • <25°C.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Synergistic with beta-lactam antibacterials agents.
  • May precipitate when in contact with other pharmaceutical agents if given through and IV infusion set.
  • Care when used in conjunction with phenylbutazone since some studies have indicated that phenylbutazone can change some of the kinetic parameters of gentamicin, eg a reduction in the half-life.
  • Diuretics can increase risk of ototoxicity.
  • Gentamicin can potentiate neuromuscular blockade with non-depolarizing muscle relaxants.
  • Increased risk of nephrotoxicity with amphotericin B and cisplatin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedpublished during the last 12 months.
  • Widmer A, Kummer M, Wehrli Eser M & Furst A (2009)Comparison of the clinical efficacy of cefquinome with the combination of penicillin G and gentamicin in equine patients.Equine Vet Educ21(8), 430-435.
  • Murchie T Aet al(2006)Continuous monitoring of penicillin G and gentamicin in allantoic fluid of pregnant pony mares byin vitromicrodialysis.Equine Vet J38(6), 520-525.
  • Booth T Met al(2001)Treatment of sepsis in the small tarsal joints of 11 horses with gentamicin-impregnated polymethylmethacrylate beads.Vet Rec148, 376-380PubMed.
  • Summerhays G E (2000)Treatment of traumatically induced synovial sepsis in horses with gentamicin-impregnated collagen sponges.Vet Rec147(7), 184-188PubMed.
  • Swan G Eet al(1995)Single and multiple dose pharmacokinetics of gentamicin administered intravenously and intramuscularly in adult conditioned thoroughbred mares.J S Afr Vet Assoc.66, 151-156PubMed.

Other sources of information

  • Bertone J & Horspool L (2004) EdsEquine Clinical Pharmacology. Saunders. ISBN: 0702024848.
  • Derived fromThe Veterinary Formulary. (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.

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