Equis ISSN 2398-2977

Furosemide

Synonym(s): Frusemide

Introduction

Name

  • Furosemide.

Class of drug

  • Loop diuretic.

Description

Chemical name

  • 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid.
  • 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid.

Molecular formula

  • C12H11ClN2O5S.

Physical properties

  • White tablets.
  • Solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

  • Used to decrease edema in conditions such as:
    • Cardiovascular and pulmonary edema.
    • Hepatic and renal dysfunction.
    • Hydrothorax.
    • Ascites.
    • Non-specific edema.
  • Is a venodilator when administered as an IV injection.
  • Claims to aid in the treatment of exercise-induced pulmonary hemorrhage (EIPH).

Administration

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Precautions

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Interactions

with other drugs

  • Acetazolamide - increased risk of hypokalemia with loop and thiazide diuretics.
  • Aminoglycosides - enhanced ototoxicity with loop diuretics.
  • Antidiabetic drugs - antagonism of hypoglycemic effect with loop and thiazide diuretics.
  • Beta-adrenoceptor blocking drugs - increased risk of ventricular arrhythmias in the presence of hypokalemia.
  • Cardiac glycosides - increased toxicity if hypokalemia occurs; enhanced effect of digoxin.
  • Cephalosporins - increased risk of nephrotoxicity.
  • Corticosteroids and corticotropin - antagonism of diuretic effect; increased risk of hypokalemia with loop and thiazide diuretics.
  • Lidocaine - lidocaine effect antagonized by hypokalemia with loop and thiazide diuretics.
  • NSAIDs - antagonism of diuretic effect.
  • Estrogens - antagonism of diuretic effect.
  • Quinidine - toxicity of quinidine is increased by hypokalemia with loop and thiazide diuretics.
  • Sulfonamides - increased risk of sulfonamide allergy.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Vengust Met al(2011)Effect of frusemide on transvascular fluid fluxes across the lung in exercising horses.Equine Vet J43(4), 451-459PubMed.
  • Bayly W Met al(2001)Effects of inhalation of albuterol sulphate, ipratroprium bomide and frusemide on breathing.Equine Vet J33(3), 302-310PubMed.
  • Soma L Ret al(2000)The effects of frusemide on racing times of Standardbred pacers.Equine Vet J32(4), 334-340PubMed.

Other sources of information

  • Derived from Bishop Y (Ed) (1998)The Veterinary Formulary.4th edn. British Veterinary Association and Royal Pharmaceutical Society.

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