ISSN 2398-2977      

Furosemide

pequis
Contributor(s):

Synonym(s): Frusemide


Introduction

Name

  • Furosemide.

Class of drug

  • Loop diuretic.

Description

Chemical name

  • 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid.
  • 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid.

Molecular formula

  • C12H11ClN2O5S.

Physical properties

  • White tablets.
  • Solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

  • Used to decrease edema in conditions such as:
    • Cardiovascular and pulmonary edema.
    • Hepatic and renal dysfunction.
    • Hydrothorax.
    • Ascites.
    • Non-specific edema.
  • Is a venodilator when administered as an IV injection.
  • Claims to aid in the treatment of exercise-induced pulmonary hemorrhage (EIPH).

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

with other drugs

  • Acetazolamide - increased risk of hypokalemia with loop and thiazide diuretics.
  • Aminoglycosides - enhanced ototoxicity with loop diuretics.
  • Antidiabetic drugs - antagonism of hypoglycemic effect with loop and thiazide diuretics.
  • Beta-adrenoceptor blocking drugs - increased risk of ventricular arrhythmias in the presence of hypokalemia.
  • Cardiac glycosides - increased toxicity if hypokalemia occurs; enhanced effect of digoxin.
  • Cephalosporins - increased risk of nephrotoxicity.
  • Corticosteroids and corticotropin - antagonism of diuretic effect; increased risk of hypokalemia with loop and thiazide diuretics.
  • Lidocaine - lidocaine effect antagonized by hypokalemia with loop and thiazide diuretics.
  • NSAIDs - antagonism of diuretic effect.
  • Estrogens - antagonism of diuretic effect.
  • Quinidine - toxicity of quinidine is increased by hypokalemia with loop and thiazide diuretics.
  • Sulfonamides - increased risk of sulfonamide allergy.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Vengust M et al (2011) Effect of frusemide on transvascular fluid fluxes across the lung in exercising horses. Equine Vet J 43 (4), 451-459 PubMed.
  • Bayly W M et al (2001) Effects of inhalation of albuterol sulphate, ipratroprium bomide and frusemide on breathing. Equine Vet J 33 (3), 302-310 PubMed.
  • Soma L R et al (2000) The effects of frusemide on racing times of Standardbred pacers. Equine Vet J 32 (4), 334-340 PubMed.

Other sources of information

  • Derived from Bishop Y (1998) Ed. The Veterinary Formulary. 4th edn. British Veterinary Association and Royal Pharmaceutical Society.
MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code