Equis ISSN 2398-2977

Diazepam

Contributor(s): Mark Senior

Introduction

Name

  • Diazepam.

Class of drug

  • Benzodiazepine, anti-epileptic drug for status epilepticus.

Description

Chemical name

  • 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one.

Molecular formula

  • C16H13ClN2O.

Physical properties

  • Tablets.
  • Solution/emulsion.

Uses

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Indications

  • Sedation   Anesthesia: standing chemical restraint  in intensive care.
  • Pre-anesthetic medication/sedation for foals under one month of age.
  • Epileptics.
  • Before myelography.
  • High risk cardiac patients.
  • Status epilepticus.

Administration

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Precautions

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Interactions

with other drugs

  • Phenobarbital   Phenobarbital   - potentiated effect with diazepam and may precipitate respiratory and cardiovascular collapse.
  • Cimetidine   Cimetidine  - increased plasma-diazepam concentration.
  • Phenytoin   Phenytoin  - reduced phenytoin metabolism.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedpublished during the last 12 months.
  • Sinclair M & Valverde A (2009)Short-term anaeshtesia with xylazine, diazepa/ketamine for castration in horses under field conditions: Use of intravenous lidocaine.Equine Vet J41(2), 149-152.

Other sources of information

  • Derived fromThe Veterinary Formulary.4th edn (1998) Bishop Y (Ed). British Veterinary Association and Royal Pharmaceutical Society.

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