Equis ISSN 2398-2977

Dexamethasone

Contributor(s): Vetstream Ltd

Introduction

Name

  • Dexamethasone.

Class of drug

  • Corticosteroid, glucocorticoid.

Description

Chemical name

  • (11-beta,16-alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione.

Molecular formula

  • C22H29FO5.

Physical properties

  • Colorless, sterile, aqueous solution.
  • Tablets.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

  • Shock.

Early administration of a large IV dose may be beneficial in circulatory failure or shock irrespective of the cause.

  • Inflammatory and allergic disorders.

Administration

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Ferris R A & McCue P M (2010) The effects of dexamethasone and prednisolone on pituitary and ovarian function in the mare. Equine Vet J 42 (5), 438-443. 
  • Leclere M, Lefebvre-Lavoie J, Beauchamp G & Lavoie J P (2010) Efficacy of oral prednisolone and dexamethasone in horses with recurrent airway obstruction in the presence of continuous antigen exposure. Equine Vet J 42 (4), 316-321 PubMed.
  • Authie E C et al (2010) Effect of an endurance-like exercise on the disposition and detection time of phenylbutazone and dexamethasone in the horse: Application to medication control. Equine Vet J 42 (3), 240-247 PubMed.
  • Cesarini C, Hamilton E, Picandet V & Lavoie J P (2006) Theophylline does not potentiate the effects of a low dose of dexamethasone in horses with recurrent airway obstruction. Equine Vet J 38 (6), 570-573 PubMed.
  • Picandet V, Leguillette R & Lavoie J P (2003) Comparison of efficacy and tolerability of isoflupredone and dexamethasone in the treatment of horses affected with recurrent airway obstruction ('heaves'). Equine Vet J 35 (4), 419-424 PubMed.
  • McCue M E, Davis E G, Rush B R, Cox J H & Wilkerson M J (2003) Dexamethasone for treatment of multisystemic eosinophilic epitheliotropic disease in a horse. JAVMA 223 (9), 1320-1323 PubMed.

Other sources of information

  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.

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