Equis ISSN 2398-2977

Detomidine hydrochloride

Contributor(s): Mark Senior, Vetstream Ltd

Introduction

Name

  • Detomidine hydrochloride.

Class of drug

  • Alpha-2 adrenoceptor stimulant.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs

  • Potentiated sulfonamides - increased risk of cardiac arrhythmias.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Pimenta E L M et al (2011) Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses. Equine Vet J 43 (3), 332-340 PubMed.
  • Love E Jet al (2011) Assessment of the sedative effects of buprenorphine administered with 10 ug/kg detomidine in horses. Vet Rec 168 (14), 379 PubMed.
  • Mama K R, Grimsrud K, Snell T & Stanley S (2009) Cardiorespiratory effects of enoximone in anaesthetised colic horses. Equine Vet J 41 (8), 772-777 PubMed.
  • Grimsrud K N, Mama K R, Thomasy S M & Stanley S D (2009) Pharmacokinetics of detomidine and its metabolites following intravenous and intramuscular administration in horses. Equine Vet J 41 (4), 361-365 PubMed.
  • Hubbell J A E et al (2009) Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise. Equine Vet J 41 (5), 419-422 PubMed.
  • Hubble J A E & Muir W W (2006) Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole. Equine Vet J 38 (3), 238-241 PubMed.
  • Nollet H, Ham Van L, Gasthuys F et al (2003) Influence of detomidine and buprenorphine on motor-evoked potentials in horses. Vet Rec 152 (17) PubMed.
  • Freeman S L & England G C W (2000) Investigation of romifidine and detomidine for the clinical sedation of horses. Vet Rec 147, 507-511 PubMed.
  • Freeman S L et al (2000) Cardiopulmonary effects of romifidine and detomidine used as premedicants for ketamine/halothane anaesthesia in ponies. Vet Rec 147, 535-539 PubMed.

Other sources of information

  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.

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