Equis ISSN 2398-2977

Detomidine hydrochloride

Contributor(s): Mark Senior, Vetstream Ltd

Introduction

Name

  • Detomidine hydrochloride.

Class of drug

  • Alpha-2 adrenoceptor stimulant.

Uses

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Indications

Administration

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Precautions

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Interactions

with other drugs

  • Potentiated sulfonamides - increased risk of cardiac arrhythmias.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Pimenta E L Met al(2011)Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses.Equine Vet J43(3), 332-340PubMed.
  • Love E Jet al(2011)Assessment of the sedative effects of buprenorphine administered with 10 ug/kg detomidine in horses.Vet Rec168(14), 379PubMed.
  • Mama K R, Grimsrud K, Snell T & Stanley S (2009)Cardiorespiratory effects of enoximone in anaesthetised colic horses.Equine Vet J41(8), 772-777PubMed.
  • Grimsrud K N, Mama K R, Thomasy S M & Stanley S D (2009)Pharmacokinetics of detomidine and its metabolites following intravenous and intramuscular administration in horses.Equine Vet J41(4), 361-365PubMed.
  • Hubbell J A Eet al(2009)Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise.Equine Vet J41(5), 419-422PubMed.
  • Hubble J A E & Muir W W (2006)antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole.Equine Vet J38(3), 238-241PubMed.
  • Nollet H, Ham Van L, Gasthuys F, Dewulf J, Vanderstraeten G & Deprez P (2003)Influence of detomidine and buprenorphine on motor-evoked potentials in horses.Vet Rec152(17)PubMed.
  • Freeman S L & England G C W (2000)Investigation of romifidine and detomidine for the clinical sedation of horses.Vet Rec147, 507-511PubMed.
  • Freeman S Let al(2000)Cardiopulmonary effects of romifidine and detomidine used as premedicants for ketamine/halothane anaesthesia in ponies.Vet Rec147, 535-539PubMed.

Other sources of information

  • Derived fromThe Veterinary Formulary4th edn (1998) Bishop, Y (Ed.). British Veterinary Association and Royal Pharmaceutical Society.

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