Equis ISSN 2398-2977

Cloprostenol sodium

Contributor(s): Vetstream Ltd, Madeleine Campbell

Introduction

Name

  • Cloprostenol.

Class of drug

  • Prostaglandin (PGF2α).

Description

Physical properties

  • Clear, colorless solution for injection.

Uses

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Indications

Licensed uses

  • Regression of the corpus luteum.
  • Induction of estrus in mares with persistent luteal function.
  • Control of cyclical ovarian activity/stud management.
  • Termination of pregnancy.
  • Treatment of lactational anestrus where that is caused by persistent corpus luteum.

Unlicensed uses

This is an off license use which should only be undertaken under the prescription cascade, and for which (written) informed consent should be obtained from animal owners prior to use.Do not use cloprostenol for this purpose after ovulation following breeding as may cause luteolysis.

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Scoggin C F (2016) Endometritis: nontraditional therapies. Vet Clin North Am Equine Pract 32, 499-511 PubMed.
  • Kuhl J, Nagel C, Ille N, Aurich J E & Aurich C (2016) The PGF2α agonists luprostiol and D-Cloprostenol reliably induce luteolysis in luteal phase mares without evoking clinical side effects or a stress response. Anim Reprod Sci 168, 92-99 PubMed.
  • Cuervo-Arango J & Newcombe J R (2012) Relationship between dose of cloprostenol and age of corpus luteum on the luteolytic response of early dioestrous mares: a field study. Reprod Domest Anim 47 (4), 660-5 PubMed.
  • Irvine C H G, McKeogh V L, Turner J E, Alexander S L & Taylor T B (2010) Effectiveness of a two-dose regimen of prostaglandin administration in inducing luteolysis without adverse side effects in mares. Equine Vet J 34 (2), 191-194 PubMed.
  • Fuchs A R (1987) Prostaglandin F2α and oxytocin interaction in ovarian and uterine function. J Steroid Biochem 27, 1073-1080 PubMed.

Other sources of information


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