Equis ISSN 2398-2977
Ceftiofur
Contributor(s): Sally Anne Argyle, Vetstream Ltd
Introduction
Name
Class of drug
Uses
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Indications
- Ceftiofur-sensitive infections: indications include equine respiratory disease caused byStreptococcusspp Streptococcus spp ,Staphylococcusspp Staphylococcus spp andPasteurellaspp Pasteurella multocida .
- As a third generation cephalosporin it has increased activity against Gram-negative bacteria as well as good Gram-positive activity.
- Broad resistance to beta-lactamase enzymes.
Administration
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Pharmocokinetics
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Precautions
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Interactions
with other drugs
- There may be an increased risk of nephrotoxicity when used in association with loop diuretics and aminoglycoside antimicrobials.
- Bacteriostatic antimicrobials may reduce the efficacy of ceftiofur.
- There may be redcued metabolism of phenylbutazone and phenytoin.
- There may be reduced barbiturate metabolism and prolongation of phenobarbital anesthesia.
Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references fromPubMed.
- Art T, Ramery E, Fraipont A & Lekeux P (2010)Pulmonary function, airway cytology and bronchoalveolar lavage fluid drug concentration after aerosol administration of cefquinome to horses.Equine Vet Educ22(9), 473-479.
Other sources of information
- Bertone J & Horspool L (2004) EdsEquine Clinical Pharmacology. Saunders. ISBN: 0702024848.
- Derived fromThe Veterinary Formulary. (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.