Equis ISSN 2398-2977

Ceftiofur

Contributor(s): Sally Anne Argyle, Vetstream Ltd

Introduction

Name

  • Ceftiofur.

Class of drug

Uses

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Indications

  • Ceftiofur-sensitive infections: indications include equine respiratory disease caused byStreptococcusspp   Streptococcus spp  ,Staphylococcusspp   Staphylococcus spp   andPasteurellaspp   Pasteurella multocida  .
  • As a third generation cephalosporin it has increased activity against Gram-negative bacteria as well as good Gram-positive activity.
  • Broad resistance to beta-lactamase enzymes.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • There may be an increased risk of nephrotoxicity when used in association with loop diuretics and aminoglycoside antimicrobials.
  • Bacteriostatic antimicrobials may reduce the efficacy of ceftiofur.
  • There may be redcued metabolism of phenylbutazone and phenytoin.
  • There may be reduced barbiturate metabolism and prolongation of phenobarbital anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Art T, Ramery E, Fraipont A & Lekeux P (2010)Pulmonary function, airway cytology and bronchoalveolar lavage fluid drug concentration after aerosol administration of cefquinome to horses.Equine Vet Educ22(9), 473-479.

Other sources of information

  • Bertone J & Horspool L (2004) EdsEquine Clinical Pharmacology. Saunders. ISBN: 0702024848.
  • Derived fromThe Veterinary Formulary. (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.

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