Introduction

Name

• Ceftiofur.

Class of drug

• 3rd generation parenterally administered beta-lactam antibacterial   Therapeutics: beta-lactam antibacterials  .

Uses

Indications

• Ceftiofur-sensitive infections: indications include equine respiratory disease caused byStreptococcusspp   Streptococcus spp  ,Staphylococcusspp   Staphylococcus spp   andPasteurellaspp   Pasteurella multocida  .
• As a third generation cephalosporin it has increased activity against Gram-negative bacteria as well as good Gram-positive activity.
• Broad resistance to beta-lactamase enzymes.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

• There may be an increased risk of nephrotoxicity when used in association with loop diuretics and aminoglycoside antimicrobials.
• Bacteriostatic antimicrobials may reduce the efficacy of ceftiofur.
• There may be redcued metabolism of phenylbutazone and phenytoin.
• There may be reduced barbiturate metabolism and prolongation of phenobarbital anesthesia.

Adverse Reactions

Further Reading

Publications

Refereed papers

• Recent references from PubMed and VetMedResource.
• Art T, Ramery E, Fraipont A & Lekeux P (2010) Pulmonary function, airway cytology and bronchoalveolar lavage fluid drug concentration after aerosol administration of cefquinome to horses. Equine Vet Educ 22 (9), 473-479.

Other sources of information

• Bertone J & Horspool L (2004) Eds. Equine Clinical Pharmacology. Saunders. ISBN: 0702024848.
• Derived from The Veterinary Formulary (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.