Equis ISSN 2398-2977

Ceftiofur

Introduction

Name

• Ceftiofur.

Class of drug

• 3rd generation parenterally administered beta-lactam antibacterial   Therapeutics: beta-lactam antibacterials  .

Uses

Indications

• Ceftiofur-sensitive infections: indications include equine respiratory disease caused byStreptococcusspp   Streptococcus spp  ,Staphylococcusspp   Staphylococcus spp   andPasteurellaspp   Pasteurella multocida  .
• As a third generation cephalosporin it has increased activity against Gram-negative bacteria as well as good Gram-positive activity.
• Broad resistance to beta-lactamase enzymes.

Administration

Pharmocokinetics

Precautions

Interactions

with other drugs

• There may be an increased risk of nephrotoxicity when used in association with loop diuretics and aminoglycoside antimicrobials.
• Bacteriostatic antimicrobials may reduce the efficacy of ceftiofur.
• There may be redcued metabolism of phenylbutazone and phenytoin.
• There may be reduced barbiturate metabolism and prolongation of phenobarbital anesthesia.

Adverse Reactions