Equis ISSN 2398-2977

Atropine sulfate

Synonym(s): Atropine sulphate, atropine

Introduction

Name

  • Atropine sulfate.

Class of drug

  • Modulator of intestinal motility, antimuscarinic pre-anesthetic medication, mydriatic and cycloplegic.

Description

Chemical name

  • Endo-(+/-)-alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester.
  • 1-alphaH,5-alphaH-tropan-3-alpha-ol(+/-)-tropate (ester).

Molecular formula

  • C17H23NO3.

Physical properties

  • Clear, sterile solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

  • Adjunct in gastrointestinal disorders characterized by smooth muscle spasm.
  • Pre-anesthetic medication.
  • Drying secretions.
  • Vagally-mediated cardiac arrhythmias.
  • Antidote for organophosphorous poisoning.
  • Relief of muscle spasm.
  • Maintenence of patent pupil.

Administration

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Pimenta E L Met al(2011)Comparative study between atropine and hyoscine-N-butylbromide for reversal of detomidine induced bradycardia in horses.Equine Vet J43(3), 332-340PubMed.

Other sources of information

  • Derived fromThe Veterinary Formulary.4th edn (1998) Bishop Y (Ed). British Veterinary Association and Royal Pharmaceutical Society.

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