Equis ISSN 2398-2977

Ampicillin

Contributor(s): Sally Anne Argyle

Introduction

Name

  • Ampicillin.

Class of drug

Description

Chemical name

  • [2S-[2-alpha,5-alpha,6-beta(S*)]]-6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Molecular formula

  • C16H19N3O4S.

Physical properties

  • Sterile, non-aqueous suspension.
  • White tablets.
  • Clear yellow aqueous solution.
  • Red and gray capsules.

Storage requirements

  • <25°C.
  • Store tablets in a dry environment.
  • Do not store in freezer.
  • Can be stored in fridge (between 2-8°C).

Uses

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Indications

  • Ampicillin-sensitive infections.
  • This includes a range of Gram-positive, Gram-negative and anaerobic organisms.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • A synergistic effect is usually described with the aminoglycosides   Therapeutics: antimicrobials  .
  • Bacteriostatic antimicrobials may reduce the efficacy of ampicillin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMedpublished during the last 12 months.
  • van den Hoven R, Hierweck B, Dobretsberger M, Ensink J M & Meijer L A (2003)Intramuscular dosing strategy for ampicillin sodium in horses, based on its distribution into tissue chambers before and after induction of inflammation.J Vet Pharmacol Ther26(6), 405-411PubMed.

Other sources of information

  • Bertone J & Horspool L (2004) EdsEquine Clinical Pharmacology. Saunders. ISBN: 0702024848.
  • Derived fromThe Veterinary Formulary. (2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society. ISBN: 0853695792.
  • Prescott J F, Baggot J D & Walker R D (2000) EdsAntimicrobial Therapy in Veterinary Medicine.3rd edn. Iowa State University Press.

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