Equis ISSN 2398-2977

Therapeutics: glucocorticoids

Contributor(s): Sally Anne Argyle, Ruth Morgan

Introduction

  • Glucocorticoids are steroid hormones produced by the adrenal glands.
  • They are controlled by a negative feedback system acting via the pituitary gland, the hypothalamus and the adrenal glands.
  • The most important naturally occurring glucocorticoid receptor present in the cytoplasm of almost all cells in the body.
  • Their actions are wide ranging and are mediated via alteration in protein expression of cells.

Actions of glucocorticoids

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Therapeutic uses for glucocorticoids

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Side effects / contraindications

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Further Reading

Publications

Refereed papers
  • Recent references fromPubMed.
  • Menendez M I, Phelps M A, Hothem E A & Bertone A L (2012)Pharmacokinetics of methylprednisolone acetate after intra-articular administration and subsequent suppression of endogenous hydrocortisone secretion in exercising horses. Am J Vet Res73(9), 1453-1461PubMed.
  • Dauvillier J, Felippe M J B, Lunn D P, Lavoie-Lamoureux A, Leclère M, Beauchamp G & Lavoie J P (2011)Effect of long-term fluticasone treatment on immune function in horses with heaves.  J Vet Intern Med25(3), 549-557PubMed.
  • Bailey S R (2010)Corticosteroid-associated laminitis. Vet Clin North Am Eq Pract26(2), 277-285PubMed.
  • Leclere M, Lefebvre-Lavoie J, Beauchamp G & Lavoie J P (2010)Efficacy of oral prednisolone and dexamethasone in horses with recurrent airway obstruction in the presence of continuous antigen exposure. Equine Vet J42(4), 316-321PubMed
  • Goodrich L R & Nixon A J (2006)Medical treatment of osteoarthritis in the horse - a review. Vet J171(1), 51-69PubMed.

Other sources of information

  • Bertone J & Horspool L (2004) Equine Clinical Pharmacology.Saunders Elsevier.


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