Equis ISSN 2398-2977 Therapeutics: chloramphenicol Preparations Preparations Chloramphenicol Chloramphenicol : Broad-spectrum. Bacteriostatic. May inhibit the bactericidal action of beta-lactam antibacterials. Do not use simultaneously Active against rickettsial and chlamydial infections. Majority of anaerobes. Most Gram-positive erobes. Non-enteric aerobes, including Actinobacillus, Bordetella, Haemophilusand Pasteurellaspp. Enterobacteriaceae, eg Escherichia coli Escherichia coli and Salmonellaspp Salmonella spp are susceptible but plasmid-mediated resistance is widespread. Unreliable activity against Mycoplasma Mycoplasmas and ureaplasmas and Proteus. Often used for suppression of secondary bacterial infections in viral disease. Used in human medicine to treat Salmonella typhi(typhoid). Do not use in animals intended for human consumption - this is prohibited Use to treat individual animals not a group Avoid drug-skin contact - wear gloves during handling and administration Readily crosses cellular barriers. Diffuses through body → sites of infection that other antibacterials cannot reach, eg cerebrospinal fluid, brain, eye. Inactivated in the liver by conjugation. Excreted in the urine and bile. Rapidly metabolized in the horse → limited use. Thiamphenicol: Similar to chloramphenicol. Florphenicol: Similar to chloramphenicol. Less likely to cause blood dyscrasias (cats). May be active against some strains resistant to chloramphenicol. See also: Therapeutics: antibacterials - overview Therapeutics: antimicrobials . Tetracyclines Therapeutics: tetracyclines . Aminoglycosides Therapeutics: aminoglycosides . Macrolides/lincosamides Therapeutics: macrolides lincosamides . Sulfonamides and potentiated sulfonamides Therapeutics: sulfonamides . Nitrofurans Therapeutics: nitrofurans / nitroimidazoles / quinolones . Further Reading PublicationsRefereed papers Recent references from PubMed and VetMedResource. Other sources of information Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop, Y. British Veterinary Association and Royal Pharmaceutical Society.