ISSN 2398-2977      

Therapeutics: chloramphenicol

pequis
Contributor(s):

Preparations

  • Chloramphenicol  Chloramphenicol  :
  • Broad-spectrum.
  • Bacteriostatic.
    May inhibit the bactericidal action of beta-lactam antibacterials. Do not use simultaneously
  • Active against rickettsial and chlamydial infections.
  • Majority of anaerobes.
  • Most Gram-positive erobes.
  • Non-enteric aerobes, including ActinobacillusBordetellaHaemophilusand Pasteurellaspp.
  • Enterobacteriaceae, eg Escherichia coli  Escherichia coli  and Salmonellaspp   Salmonella spp  are susceptible but plasmid-mediated resistance is widespread.
  • Unreliable activity against Mycoplasma  Mycoplasmas and ureaplasmas  and Proteus.
  • Often used for suppression of secondary bacterial infections in viral disease.
  • Used in human medicine to treat Salmonella typhi(typhoid).
    Do not use in animals intended for human consumption - this is prohibited
    Use to treat individual animals not a group
    Avoid drug-skin contact - wear gloves during handling and administration
  • Readily crosses cellular barriers.
  • Diffuses through body   →   sites of infection that other antibacterials cannot reach, eg cerebrospinal fluid, brain, eye.
  • Inactivated in the liver by conjugation.
  • Excreted in the urine and bile.
  • Rapidly metabolized in the horse   →   limited use.
  • Thiamphenicol:
  • Similar to chloramphenicol.
  • Florphenicol:
  • Similar to chloramphenicol.
  • Less likely to cause blood dyscrasias (cats).
  • May be active against some strains resistant to chloramphenicol.
  • See also:

Further Reading

Publications

Refereed papers

Other sources of information

  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop, Y. British Veterinary Association and Royal Pharmaceutical Society.

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field

 Security code