ISSN 2398-2977      

Therapeutics: beta-lactam antibacterials

pequis

Introduction

  • Beta-lactam antimicrobials are a large group comprising penicillins and cephalosporins.
  • Bactericidal - interfere with cell-wall synthesis.
  • Not metabolized.
  • Excreted unchanged in the urine. Since they undergo both filtration and active tubular secretion, high concentrations are achieved in the urinary tract.
  • Distribution is limited. Although inflammation may aid tissue penetration, in general, these antibiotics do not penetrate well into CNS, mammary or prostatic tissue.
  • Low-solubility preparations can be used as depot injections to prolong action, but lower concentrations are achieved in body fluids.

High initial concentrations plus long duration of action can be achieved by giving a soluble and a less soluble penicillin salt simultaneously.

Penicillins

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Beta-lactamase inhibitors

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Cephalosporins

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Further Reading

Publications

Refereed papers

Other sources of information

  • Derived from The Veterinary Formulary. 5th edn (2001) Ed: Bishop Y. Pharmaceutical Press & British Veterinary Association, UK.
  • Adams R H (2001) Ed. Veterinary Pharmacology and Therapeutics. Iowa State University Press, USA.
  • Prescott, Baggot & Walker (2000) Eds. Antimicrobial Therapy in Veterinary Medicine. 3rd edn. Iowa State University Press, USA.

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