Equis ISSN 2398-2977

Therapeutics: antimicrobials - regional distal limb perfusion

Contributor(s): Sally Anne Argyle, Patrick Pollock

Introduction

  • technique used to achieve high local concentrations of antimicrobial in the distal limb.
  • Reduced infection rates. 
  • Increased survival rates.
  • Achieves antimicrobial concentrations higher than the MIC for up to 24 h - this can be particularly beneficial in the case of poorly distributed antimicrobials like gentamicin and amikacin which when administered systemically may struggle to achieve high concentrations at local sites of infection.

Uses

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Decision taking

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Requirements

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Preparation

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Procedure

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Parra-Sanchez A, Lugo J et al (2006) Pharmacokinetics and pharmacodynamics of enrofloxacin and a low dose of amikacin administered via regional intravenous limb perfusion in standing horses. Am J Vet Res 67 (10), 1687-1695 PubMed.
  • Rubio-Martínez L M & Cruz A M (2006) Antimicrobial regional limb perfusion in horses. JAVMA 228 (5), 655, 706-712 PubMed.
  • Pille F, De Baere S, Ceelen L et al (2005) Synovial fluid and plasma concentrations of ceftiofur after regional intravenous perfusion in the horse. Vet Surg 34 (6), 610-617 PubMed.
  • Werner L A, Hardy J & Bertone A L (2003) Bone gentamicin concentrations after intr-articular injection or regional intravenous perfusion in the horse. Vet Surg 32 (6), 559-565 PubMed.


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