Equis ISSN 2398-2977

Therapeutics: anti-inflammatory drugs

Synonym(s): NSAIDS, corticosteroids

Contributor(s): Sally Anne Argyle, Graham Munroe, Vetstream Ltd

Introduction

  • Anti-inflammatory drugs are used to reduce the signs of acute inflammation.
  • Usually   →   relieve pain and reduce swelling.
  • For the treatment of musculoskeletal disorders, anti-inflammatories act upon inflammatory mediators and modulators, eg:
    • Histamine.
    • Bradykinin.
    • Prostaglandins.
    • Leukotrienes.
    • Thromboxanes.
    • Platelet-activating factor.
    • Complement components.
    • Lysosomal and non-lysosomal enzymes.
    • Nitric oxide.
    • Oxygen derived free radicals.
  • Action may only suppress, not abolish, inflammatory effects of mediators.
  • For the treatment of skin conditions   Therapeutics: skin  , oral corticosteroids are useful acutely and for chronic disease (where alternate-day therapy is necessary to avoid adrenal suppression).

Non-steroidal anti-inflammatory drugs (NSAIDs)

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Corticosteroids

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • McIlwraith C W (2010) The use of intra-articular corticosteroids in the horse: What is known on a scientific basis? Equine Vet J 42 (6), 563-571 PubMed.
  • Fennell L C & Franklin R P (2009) Do non-steroidal anti-inflammatory drugs administered at therapeutic dosages induce gastric ulcers in horses? Equine Vet Educ 21 (12), 660-662.
  • Schleining J A & Reinertson E L (2007) Evidence for dimethyl sulfoxide (DMSO) use in horses. Part 2: DMSO as a parenteral anti-inflammatory agent  and as a pharmacological carrier. Equine Vet Educ 19 (11), 598-599.

Other sources of information

  • Kollais-Baker C & Cox K (2004) Non-Steroidal Anti-Inflammatory drugs. In: Equine Clinical Pharmacology. Eds: Bertone J J & Horspool L J I. Saunders, UK. pp 247-265.
  • Derived from The Veterinary Formulary (2001) 5th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.


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