ISSN 2398-2977      

Muscle: biopsy

pequis

Introduction

  • Muscle biopsy is an under utilized technique that can provide valuable information about the etiology of neuromuscular conditions.
  • It would be primarily used in the investigation of recurrent or rhabdomyolysis   Muscle: myopathy - exertional rhabdomyolysis  and muscle wasting associated with neuromuscular disease, particularly suspected EMND   Neurology: motor neuron disease  .
  • While typically used for generalized muscle disorders, it is also useful for localized muscle disorders, eg myositis.

Indications

  • Recurrent rhabdomyolysis   Muscle: myopathy - exertional rhabdomyolysis  .
  • Shivering.
  • Hindlimb weakness.
  • Hindlimb muscle atrophy   Hindlimb: muscle atrophy 01    Hindlimb: muscle atrophy 02  .
  • Generalized weakness and atrophy.
  • Local muscle swelling, pain or atrophy of unknown etiology.

techniques for recurrent rhabdomyolysis

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techniques for neuromuscular disorders: equine motor neuron disease

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techniques for localized muscle disorders

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Sampling, handling and processing

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Stanley R L, Maile C & Piercy R J (2009) Storage-associated artefact in equine muscle biopsy sample. Equine Vet J 41 (1), 82-86.
  • Ledwith A & McGowan C M (2004) Muscle biopsy: a routine diagnostic procedure. Equine Vet Educ 16 (2), 62-67.
  • Valentine B A, Divers T J et al (1998) Muscle biopsy diagnosis of motor neuron disease and equine polysaccharide storage myopathy. Equine Vet Educ 10, 42-50.

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