Equis ISSN 2398-2977

Liver disease: overview

Contributor(s): Joe Bertone, Susan Dawson, Debbie Deem Morris, Imogen Johns, Timothy Mair

Physiology

Functions of liver
  • Digestive and secretory function, eg bile salts for fat emulsification.
  • Metabolism of carbohydrate, protein and fat.
  • Detoxification/excretory function.
  • Synthesis of clotting factors and proteins.
  • Storage of vitamins and minerals.

Liver disease

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Pathogenesis

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Clinical signs

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Diagnosis

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Treatment

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Further Reading

Publications

Refereed papers
  • Recent references fromPubMed.
  • Johns I C (2008)Coagulation abnormalities and complications after percutaneous liver biopsy in horses. J Vet Intern Med22(1), 185-189PubMed.
  • Ramaiah S K et al(2003)Intravascular hemolysis associated with liver disease in a horse with marked neutrophil hypersegmentation. J Vet Intern Med17(3), 360-363PubMed.
  • Smith M R W, Stevens K B, Durham A E & Marr C M (2003)Equine Hepatic disease: the effect of patient- and case-specific variables on risk and prognosis. Equine Vet J35(6), 459-552PubMed.
  • Durham A E, Newton J R etal (2003)Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease. Equine Vet J35(6), 542-547PubMed.
  • Byars T D (2003)Liver disease: contributions to diagnostic and prognostic aids. Equine Vet J35(6), 522-523PubMed.
  • Curran J M et al(1996)A screening test for subclinical liver disease in horses affected by pyrrolizidine alkaloid toxicosis. Aust Vet J74(3), 236-240PubMed.
  • West H J (1996)Clinical and pathological studies in horses with hepatic disease. Equine Vet J28(2), 146-156PubMed.
  • Mogg T D et al(1995)Hyperlipidemia, hyperlipemia and hepatic lipidosis in American miniature horses - 23 cases (1990-1994). JAVMA207(5), 604-607PubMed.
  • Guglick M A et al(1995)Hepatic disease associated with administration of tetanus antitoxin in eight horses. JAVMA206(11) 1737-1740PubMed.
  • Parraga M E et al(1995)Serum protein concentrations in horses with severe liver disease: a retrospective study and review of the literature. J Vet Intern Med9(3), 154-161PubMed.
  • Durando M M et al(1995)Septic cholangiohepatitis and cholangiocarcinoma in a horse. JAVMA206(7), 1018-1021PubMed.
  • Woods P R (1995)Internal diseases that have skin lesions. Vet Clin North Am Equine Pract11(1), 111-126.
  • Messer N T 4th et al(1994)Idiopathic acute hepatic disease in horses - 12 cases (1982-1992). JAVMA204(12), 1934-1937.
  • Messer N T 4th et al(1994)Serum hepatitis in two brood mares. JAVMA204(11), 1790-1792.
  • Pearson E G et al(1994)Hepatic cirrhosis and haemochromatosis in three horses. JAVMA204(7), 1053-1056.
  • Zientara S et al(1994)Survey of equine hepatic encephalopathy in France in 1992. Vet Rec134(1), 18-19.
  • Chaffin M K et al(1992)Ultrasonographic characteristics of splenic and hepatic lymphosarcoma in three horses. JAVMA201(5), 743-737.
  • Acland H M et al(1984)Toxic hepatopathy in neonatal foals. Vet Pathol21(1), 3-9.
  • Mullaney T P, Brown C M, Watson G L & Brandt L A (1984)Suspected hepatotoxicity in neonatal foals - preliminary report of an emerging syndrome. Vet Rec114(5), 115-117.
  • Robinson M, Gopinath C & Highes D L (1975)Histopathology of acute hepatitis in the horse. J Comp Pathol85(1), 111-118.
  • Swerczek T W, Crowe M W, Prickett M E & Bryans J T (1973)Focal bacterial hepatitis in foals - preliminary report. Mod Vet Pract54(11), 66-67.
  • Tennant B C, Evans C D, Kaneko J J & Schalm O W (1972)Hepatic failure in the horse. Mod Vet Pract53(12), 40-42.
  • Thomsett L R (1971)Acute hepatic failure in the horse. Equine Vet J3(1), 15-19.


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