Equis ISSN 2398-2977
Eye: drug administration - systemic
Contributor(s): Dennis E Brooks, Graham Munroe
- Systemic administration of drugs for eye conditions is compromised by the blood-ocular barriers (blood-aqueous and blood-retinal) and removal by active transport systems.
- These barriers become compromised in inflammatory conditions due to leaking capillary endothelium and many agents, particularly antibiotics, can achieve high intra-ocular levels at certain dose rates.
- Chloramphenicol and sulfa drugs penetrate these barriers adequately.
- Intravenous administration is the preferred route, leading to high plasma peak levels and high intra-ocular levels subsequently.
- Unfortunately, the high systemic doses required to reach adequate intraocular levels may increase the risk of systemic side-effects.
- Systemic medication is useful:
- As a pre- and post-operative measure in intra-ocular surgery.
- For the treatment of:
- Acute bacterial uveitis Uveitis: bacterial .
- Posterior segment infections.
- Eyelid and orbital diseases (high vascularity).
- Deep corneal problems .
- Nasolacrimal disease.
Other sources of information
- Brooks D E (1999) Equine Ophthalmology. In: Veterinary Opthalmology.Ed: Gelatt K N. 3rd edn pp 1053-1116.