Equis ISSN 2398-2977

Bone marrow: disorders - overview

Contributor(s): Katherine Edgar, Prof Derek Knottenbelt, Ruth Morgan

Introduction

  • Bone marrow disorders are characterized by the loss of normal marrow architecture   Bone marrow: normal - pathology  .
  • This is replaced by fibrosis or the unregulated proliferation of bone marrow derived erythroid, lymphoid, myeloid and megakaryocyte blood cell lines.
  • Most disorders are rare in horses with infrequent reports in the literature.
  • Lymphoproliferative disorders are the most common.

Classification

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Clinical signs

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Diagnosis

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Cudmore L et al (2012) Pancytopenia in two horses following administration of potentiated sulfonamide antimicrobials. Equine Vet Educ.
  • Delling U et al (2012) Comparison of bone marrow aspiration at the sternum and the tuber coxae in middle-aged horses. Can J Vet Res 76 (1), 52-56 PubMed.
  • Durando M M et al (2006) Pneumopericardium in a horse secondary to sternal bone marrow aspiration. Equine Vet Educ 18 (2), 75-79 VetMedResource.
  • Noble G et al (2012) Pharmacokinetics and safety of single and multiple oral doses of meloxicam in adult horses. J Vet Intern Med 26 (5), 1192-1201 PubMed.
  • Norman T E et al (2012) B cell lymphoma and secondary leukaemia in a mule. Equine Vet Educ 24 (12), 599-603 VetMedResource.
  • McClure J T (2000) Leukoproliferative disorders in horses. Vet Clin North Am Equine Pract 16 (1), 165-182 PubMed.
  • Savage J C (1998) Lymphoproliferative and myeloproliferative disorders. Vet Clin North Am Equine Pract 14 (3), 563-578 PubMed.
  • Kohn C W, Swardson C, Provost P et al (1995) Myeloid and megakaryocytic hypoplasia in related standardbreds. J Vet Intern Med (5), 315-323 PubMed.
  • Lavoie J-P, Morris D D, Zinkl J et al (1987) Pancytopenia caused by bone marrow aplasia in a horse. JAVMA 191, 1462-1464 PubMed.

Other sources of information

  • Savage C J (1996) Bone Biopsy Evaluation of Equine Bone Marrow. In: Proc 14th ACVIM Annual Meeting. pp 569-570.


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