Equis ISSN 2398-2977

Skin: neoplasia - mast cell tumor

Synonym(s): Cutaneous mastocytoma, Cutaneous mastocytosis

Contributor(s): Janet D Littlewood, Sue Paterson, Vetstream Ltd, Anna Hollis

Introduction

  • Usually a hyperplastic process rather than neoplastic, self-limiting disease.
  • Three forms reported:
    • Cutaneous nodules.
    • Malignant mast cell tumors.
    • Congenital mast cell tumors.
  • Cause: unknown. May represent a hypersensitivity response to the migration of Onchocerca spp or other inflammatory or autoimmune reactions, but there is no evidence to support these theories.
  • Signs: usually single nodule on head, neck or distal extremities.
  • Diagnosis: total excision biopsy.
  • Treatment: surgical excision.
  • Prognosis: good, except in the malignant form.

Pathogenesis

Pathophysiology

  • Unknown.

Diagnosis

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Treatment

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Barrelet A, Foote A & Littlewood J D (2010) Common equine skin tumours. UK Vet 15 (6), 9-17 VetMedResource.
  • Brown J A et al (2008) Unilateral testicular mastocytoma in a Peruvian Paso stallion. Equine Vet Educ 20 (4), 172-175 VetMedResource.
  • Mair T S & Krudewig C (2008) Mast cell tumors (mastocytosis) in the horse: A review of the literature and report of 11 cases. Equine Vet Educ 20 (4), 177-182 VetMedResource.
  • Henson F M D & Dobson J M (2004) Use of radiation therapy in the treatment of equine neoplasia. Equine Vet Educ 16 (6), 315-318 VetMedResource.
  • Kay G, Noursaid T, El Hamidi M & Perron M F (2003) Grade III mastocytoma in a donkey. Vet Rec 152 (9), 266-267 PubMed.
  • Quinn G (2003) Skin tumours in the horse: clinical presentation and management. In Pract 25 (8), 476-483 VetMedResource.
  • Mathison P T (1995) Eosinophilic nodular dermatoses. Vet Clin North Am Equine Pract 11 (1), 75-89 PubMed.
  • McEntee M F (1991) Equine cutaneous mastocytoma - morphology, biologic behavior and evolution of the lesion. J Comp Pathol 104 (2), 171-178 PubMed.
  • Riley C B et al (1991) Malignant mast cell tumors in horses. Aust Vet J 68 (10), 346-347 PubMed.

Other sources of information

  • Knottenbelt D C, Patterson-Kane J C & Snalune K L (2015) Clinical Equine Oncology. Elsevier, UK.


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